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The Clinical Pharmacokinetics of Quinapril
Angiology, 1989Quinapril (Q) and quinaprilat (QT) pharmacokinetics are dose pro portional following single oral 2.5- to 80-mg Q doses. Q absorption and hy drolysis to QT is rapid with peak Q and QT concentrations occurring one and two hours postdose, respectively.
Stephen C. Olson +6 more
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The Safety and Tolerability of Quinapril
Journal of Cardiovascular Pharmacology, 1990Quinapril, a new angiotensin-converting enzyme (ACE) inhibitor with an intermediate duration of action, has been extensively studied in patients with hypertension and congestive heart failure (CHF) during a worldwide clinical development program. A comprehensive safety data base was established to allow appropriate analyses of the extensive patient ...
L E, Knapp +5 more
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Anti-inflammatory Actions of Quinapril
Cardiovascular Drugs and Therapy, 2007The role of angiotensin II (Ang-II) in inflammation and the mechanisms through which it exerts this role are explored. Signaling through angiotensin stimulation of inflammatory cells often amplifies inflammation. Formation of Ang-II from tissue angiotensin-converting enzyme (ACE) has been shown to be of greater importance in the development and ...
Jesus, Egido, Marta, Ruiz-Ortega
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Quinapril in Chronic Heart Failure
American Journal of Hypertension, 1990Angiotensin converting enzyme inhibitors are now firmly established in the treatment of patients with chronic heart failure (CHF). Their beneficial acute and chronic hemodynamic effects are not associated with reflex tachycardia or drug tolerance. Angiotensin converting enzyme inhibitors produce symptomatic improvement and improve exercise capacity in ...
D B, Northridge, H J, Dargie
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Use of Quinapril in the Elderly Patient
American Journal of Hypertension, 1990Quinapril hydrochloride is a nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor that has been extensively tested and found effective when administered once-a-day to hypertensive patients of both sexes and all degrees of hypertension and cardiac compromise, including those with left ventricular hypertrophy, with and without congestive heart ...
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