Results 101 to 110 of about 387 (133)

Synthesis and in vitro biological evaluation of novel quinazoline derivatives

Bioorganic & Medicinal Chemistry Letters, 2017
A series of novel 4-arylamino-6-(5-substituted furan-2-yl)quinazoline derivatives were designed, synthesized and evaluated on biological activities in vitro. Compound 2a, 3a and 3c exhibited highly anti-proliferation activities on all tested tumor cell lines including SW480, A549, A431 and NCI-H1975 cells.
Yaling, Zhang, Ying, Zhang, Juan, Liu, Li, Chen, Lijun, Zhao, Baolin, Li, Wei, Wang   +6 more
openaire   +2 more sources

New synthesis of quinazoline and benzoquinazoline derivatives

Tetrahedron Letters, 1983
Abstract The synthesis of 2-substituted quinazolines II from 1,3-diazabutadienes I and of benzoquinazolines IV and VI from N-naphthylsubstituted amidines III and V the yields being up to 90% is reported.
openaire   +1 more source

Quinazoline derivatives as kinase inhibitors

2011
The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinase and treating disese states in a mammal by inhibiting the ...
MILLENNIUM PHARM INC, KYOWA HAKKO KOGYO KK   +1 more
openaire   +1 more source

Quinazoline derivatives as novel bacterial sphingomyelinase enzyme inhibitors

Bioorganic Chemistry
Bacillus cereus sphingomyelinase C (B. cereus SMase), which plays a crucial role in bacterial virulence, has emerged as a new therapeutic target for treating opportunistic infections caused by this pathogen. It also shares catalytic domain similarity with human neutral sphingomyelinase 2 (nSMase2), which is implicated in Alzheimer's disease.
Ozge Kuyrukcu Ozturk, Ozlem Oyardi, Yasemin Dundar   +2 more
openaire   +3 more sources

42. Derivatives of quinazoline

Journal of the Chemical Society (Resumed), 1936
T. M. Reynolds, Robert Robinson
openaire   +1 more source

An Insight on the Prospect of Quinazoline and Quinazolinone Derivatives as Anti-tubercular Agents

Current Organic Synthesis, 2023
Adarsh Sahu
exaly  

An Updated Overview on the Synthesis and Anticancer Evaluation of Quinazoline Derivatives

ChemistrySelect, 2023
Jasneet Kaur
exaly  

Design, synthesis, crystal structure, and antimicrobial activities of new quinazoline derivatives containing both the sulfonate ester and piperidinylamide moieties

Pest Management Science, 2023
Xiaoping Bao
exaly  

Activity of Quinazoline Derivatives: A Review

Asian Journal of Research in Pharmaceutical Science, 2017
D. D. Rishipathak, A. B. Kokate, K. S. Madhawai   +2 more
openaire   +1 more source

Quinazolinone and Quinazoline Derivatives

2020
openaire   +1 more source