Results 171 to 180 of about 10,618 (207)
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Quinazolines. Part VIII. Electronic effects in 2-substituted quinazolines
Journal of the Chemical Society C: Organic, 1966In a study of the cations of twenty 2-substituted quinazolines, it was found that covalent hydration of the 3,4-double bond decreased according to the electronic effect of the 2-substituent; viz, +l > +M > –l. This is explained by the effect of the substituent on the polarity of the C-4, N-3 double bond. The effect of the acyl group on the rate of ring
W. L. F. Armarego, J. I. C. Smith
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Pharmacology, 1971
Piquizil, a 4-aminoquinazoline causing relaxation of respiratory smooth muscle in animals, appeared to be a bronchodilator in man. A metabolite of piquizil was isolated from human urine and identified. This metabolite, named hoquizil, had a longer plasma half-time than piquizil, was generally of comparable pharmacological activity, but was better ...
M. Schach von Wittenau, T.F. Brewer
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Piquizil, a 4-aminoquinazoline causing relaxation of respiratory smooth muscle in animals, appeared to be a bronchodilator in man. A metabolite of piquizil was isolated from human urine and identified. This metabolite, named hoquizil, had a longer plasma half-time than piquizil, was generally of comparable pharmacological activity, but was better ...
M. Schach von Wittenau, T.F. Brewer
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1984
Quinazoline (1) is a building block for approximately eighty naturally occurring alkaloids isolated from a number of families of the plant kingdom, from microorganisms and from animals. The first known quinazoline alkaloid was vasicine (peganine), isolated in 1888 from Adhatoda vasica, and later from other species.
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Quinazoline (1) is a building block for approximately eighty naturally occurring alkaloids isolated from a number of families of the plant kingdom, from microorganisms and from animals. The first known quinazoline alkaloid was vasicine (peganine), isolated in 1888 from Adhatoda vasica, and later from other species.
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Tetrahedron, 1986
Abstract Grignard reagents reacted with 2-aminobenzonitrile to give the intermediate 10 , which readily could be cyclized to quinazolines by reaction with carbonyl compounds (e.g. acid chlorides, anhydrides, formates and oxalates). The intermediate 10 and aldehydes, e.g.
Jan Bergman +3 more
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Abstract Grignard reagents reacted with 2-aminobenzonitrile to give the intermediate 10 , which readily could be cyclized to quinazolines by reaction with carbonyl compounds (e.g. acid chlorides, anhydrides, formates and oxalates). The intermediate 10 and aldehydes, e.g.
Jan Bergman +3 more
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5-Substituted quinazoline antifolates
European Journal of Cancer (1965), 1980Abstract Two new 5 -substituted- 2 -amino- 4 -hydroxy-quinazoline antifolates are described. The presence of the 5 -substituent reduced the inhibitory effect upon thymidylate synthetase. In contrast, the 2,4 -diaminoquinazoline series, the same 5 -substituents improved the inhibition.
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Quinazoline derivatives with antitubercular activity
Il Farmaco, 20004-Quinazolinol was prepared by the reaction of anthranilic acid and formamide. The hydroxy group was converted into the thiol function by treatment with phosphorus(V)sulfide, and the subsequent alkylation of the thiol group was carried out with alkylhalides under the conditions of phase-transfer catalysis.
J, Kunes +5 more
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Synthesis of Quinazolinones and Quinazolines
ChemInform, 2005AbstractFor Abstract see ChemInform Abstract in Full Text.
David J. Connolly +3 more
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Quinazolines. VIII. Synthesis of 1,3‐diaminobenzo[f]quinazolines
Journal of Heterocyclic Chemistry, 1972AbstractTwenty‐one 1,3‐diaminobenzo[f]quinazolines (2, R = H, alkyl, halogen, methoxy) were synthesized as planar tricyclic analogs of the antimalarial agent pyrimethamine (1). The synthetic methods included i) condensation of 1‐cyano‐2‐naphthylamines with cyanamide in the presence of pyridine hydrochloride, ii) cyclization of N1,N5‐bis(2‐naphthyl ...
Andre Rosowsky +4 more
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ChemInform, 2008
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Carlos M. Martinez‐Viturro +1 more
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AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Carlos M. Martinez‐Viturro +1 more
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2015
The present invention relates to quinazoline compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: (Formula (I)) wherein X, R1, R2, R3, R4, R5, R6 and R7 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical ...
Goldberg,, Kristin +7 more
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The present invention relates to quinazoline compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: (Formula (I)) wherein X, R1, R2, R3, R4, R5, R6 and R7 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical ...
Goldberg,, Kristin +7 more
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