Results 211 to 220 of about 26,162 (241)

Advances in the Synthesis of Heterocyclic Compounds and Their Applications. [PDF]

Molecules
Mangalagiu II, Darabantu M.
europepmc   +1 more source

Engineering Lipid Nanoparticles for Precision RNA Delivery: Design Principles, Targeting Strategies, and Clinical Prospects

Cancer Nexus, Volume 2, Issue 2, April 2026.
ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han, Ying Wang, Xintao Gao, Yan Lei, Yantao Li, Zhiyong Tang   +5 more
wiley   +1 more source

General Approach To Access Aldehyde Oxidase Metabolites of Drug Molecules via <i>N-</i>Oxidation/Reissert-Henze-Type Reaction. [PDF]

Org Lett
Hanneman CM, Song S, Onuska NPR, Ruble JC, Stahl SS.   +4 more
europepmc   +1 more source

Antiplasmodial Activity and Pharmacokinetic Profiling of Cryptolepine and 2,7‐Dibromocryptolepine With a View to Informing the Design of Novel Antimalarial Cryptolepine Analogues

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT The roots of the climbing shrub Cryptolepis sanguinolenta are traditionally used in West Africa for the treatment of malaria. The principal constituent, cryptolepine (1), has been shown to have antimalarial activity but there are concerns regarding its toxicity on account of its DNA‐intercalating property.
Elodie Chenu, James Duffy, Arnold Donkor Forkuo, Stephen Y. Gbedema, Seham Abdelall, Muhammad Wahajuddin, Huw S. Jones, Colin W. Wright   +7 more
wiley   +1 more source

Hydrogenation of Quinolines and Aldehydes Catalyzed by a Pyrolyzed, Augmented Cobalt-Salen Complex. [PDF]

ACS Omega
Schmiedbauer F, Monkowius U, Schwarzinger C, Müllegger S, Bartling S, Rockstroh N, Topf C.   +6 more
europepmc   +1 more source

Heat‐Induced Toxicants: Sensory Appeal Distracts Consumers' Attention From Potential Toxicological Risks of Thermally Processed Foods

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
The central paradox of thermal processing of foods. (A) The application of heat (e.g., frying, baking, grilling) to food initiates complex chemical reactions, most notably the Maillard reaction and thermal degradation of protein, lipids, and carbohydrate. (B) These reactions create a desirable sensory experience characterized by enticing aromas, golden‐
Joachim Dotto Matondo, Abdulsudi Issa‐Zacharia   +1 more
wiley   +1 more source

Selective Synthesis of Imidazo[4,5‑<i>f</i>]- and Imidazo[4,5‑<i>h</i>]quinoline <i>N</i>‑Oxides via Base-Catalyzed Cyclization of <i>ortho</i>-Nitroalkylaminoquinolines. [PDF]

ACS Omega
Larin AN, Pobedinskaya DY, Borovlev IV, Avakyan EK, Borovleva AA, Ermolenko AP, Demidov OP.   +6 more
europepmc   +1 more source

Benzimidazole-Quinoline Hybrids: Synthesis and Antimicrobial Properties. [PDF]

Pharmaceuticals (Basel)
Marinescu M.
europepmc   +1 more source

Glandular quinoline-derivates protect crustacean woodlice from spider predation. [PDF]

J R Soc Interface
Fischer A, Gries R, Roman-Torres CA, Devireddy A, Gries G.   +4 more
europepmc   +1 more source