Results 121 to 130 of about 136,091 (317)

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Review Article: Classic Bismuth Quadruple Therapy for Helicobacter pylori Infection—Questions Focused on Clinical Practice

Alimentary Pharmacology &Therapeutics, EarlyView.
BQT remains the most effective, safe, and practical regimen for H. pylori eradication, ensuring high cure rates across diverse resistance patterns and clinical settings. ABSTRACT Background Classic bismuth quadruple therapy (BQT)—the combination of a proton pump inhibitor, bismuth, tetracycline, and metronidazole—is a standard regimen for treating ...
Javier P. Gisbert, Pablo Parra, Olga P. Nyssen   +2 more
wiley   +1 more source

Ofloxacin plus Rifampicin versus Doxycycline plus Rifampicin in the treatment of brucellosis: a randomized clinical trial [ISRCTN11871179]

BMC Infectious Diseases, 2004
Background The combination therapies recommended by the World Health Organization for treatment of brucellosis are doxycycline plus rifampicin or doxycycline plus streptomycin. Although highly successful results have been obtained with these two regimens,
Kayas Derya, Sencan Irfan, Karabay Oguz, Şahin Idris   +3 more
doaj   +1 more source

Usefulness of In Vivo and In Vitro Diagnostic Tests in the Diagnosis of Hypersensitivity Reactions to Quinolones and in the Evaluation of Cross-Reactivity: A Comprehensive Study Including the Latest Quinolone Gemifloxacin

Allergy Asthma and Immunology Research, 2017
Purpose Reports evaluating diagnosis and cross reactivity of quinolone hypersensitivity have revealed contradictory results. Furthermore, there are no reports investigating the cross-reactivity between gemifloxacin (GFX) and the others.
S. Demir, A. Gelincik, Nilgun Akdeniz, E. Aktas-Cetin, M. Olgac, D. Unal, Belkıs Ertek, Raif Coşkun, B. Çolakoğlu, G. Deniz, S. Buyukozturk   +10 more
semanticscholar   +1 more source

Protein tyrosine phosphatases as emerging targets for cancer immunotherapy

British Journal of Pharmacology, EarlyView.
Abstract Contemporary strategies in cancer immunotherapy, despite remarkable success, remain constrained by inherent limitations such as suboptimal patient responses, the emergence of drug resistance, and the manifestation of pronounced adverse effects. Consequently, the need for alternative strategies for immunotherapy becomes clear.
Zihan Qu, Jiajun Dong, Zhong‐Yin Zhang
wiley   +1 more source

Microbiome‐Based Modeling of CAR‐T Therapy Response in Lymphoma: Insights From Shotgun Metagenomics Sequencing

European Journal of Haematology, EarlyView.
ABSTRACT The interplay between the commensal microbiota and the mammalian immune system may influence the outcomes of T cell‐driven cancer immunotherapies. However, clinical studies supporting microbiota‐based interventions in chimeric antigen receptor T‐cell (CAR‐T) therapy remain scarce.
Rafael Hernani, Eliseo Albert, Carlos Hernani‐Morales, Sheila Zúñiga, Ana Benzaquén, Laura González‐Castillo, Ester Colomer, Júlia Morell, José Francisco Català‐Senent, José Luis Piñana, Estela Giménez, Ariadna Pérez, Juan Carlos Hernández‐Boluda, Ignacio Arroyo, Marcos Rivada, Teresa Barber, Teresa Alemany, Enric Santacatalina, Pilar Rentero‐Garrido, María José Terol, Rafael Díaz, David Navarro, Carlos Solano   +22 more
wiley   +1 more source

Antibiotic resistance in the environment, with particular reference to MRSA [PDF]

, 2008
The introduction of β-lactam antibiotics (penicillins and cephalosporins) in the 1940s and 1950s probably represents the most dramatic event in the battle against infection in human medicine.
Aarestrup, Abraham, Agerso, Agustía, Anthonisen, Archer, Armand‐Lefevre, Asensio, Aubry‐Damon, Baptiste, Bass, Berg, Berghash, Bernabé, Biberstein, Boag, Bonnet, Boxall, Boyle‐Vavra, Briggs, Brinas, Brinas, Brinas, Burd, Burd, Burrus, Busato, Cefai, Chapin, Chee‐Sanford, Chen, Coello, Coffey, Couto, Couto, Cove, Dar, Daum, Davidson, De Liguoro, de Neeling, De Oliveira, Decousser, Devriese, Dingwell, Dunny, Eady, Ensor, Erskine, Fanaro, Fluit, Fox, Freter, Gaze, Gentilini, Germida, Gibbs, Gill, Golet, Gotz, Griggs, Guler, Halbert, Hall, Hamscher, Hansen‐Nord, Hanssen, Hanssen, Hardy, Hartman, Hasman, Hawes, Hawkey, Henriques, Herold, Heuer, Heuer, Hiramatsu, Hoekstra, Hollander, Holmes, Huijsdens, Hutchison, Ito, Ito, Jensen, Kapur, Katayama, Kirby, Kloos, Kummerer, Kuroda, Lee, Lee, Leverstein‐van Hall, Levy, Levy, Lilenbaum, Lindsay, Livermore, Lopes, Machado, Mahamoud, Manian, Marangon, McDonnell, Menzies, Mesa, Morales, Nandi, Neely, Nemergut, Nield, Nordmann, Owen, Owens, Partridge, Patel, Paulsen, Peacock, Pengov, Piddock, Piddock, Pirnay, Poirel, Poirel, Poirel, Poirel, Rahme, Raviglione, Recchia, Roberson, Robicsek, Rodriguez, Sapkota, Sasatsu, Sato, Sato, Segal, Seguin, Shea, Shiraki, Shukla, Sidhu, Sidhu, Singer, Smalla, Smit, Smith, Sorum, Stokes, Tennstedt, Tiemersma, Tikofsky, Tomlin, Top, Turtura, Turutoglu, van Den Bogaard, van den Bogaard, van Duijkeren, van Duijkeren, Vengust, Voss, Waldron, Weese, Weese, Weese, Weigel, White, Witte, Witte   +171 more
core   +1 more source

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

The FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova, Angelina Osipyan, Lili Zhang, Matthew R. Groves, Sandy Schmidt, Kristina Haslinger   +5 more
wiley   +1 more source

Estudios de acoplamiento molecular de nuevos análogos de quinolonas a la ADN girasa de Escherichia coli [PDF]

, 2018
Indexación: Scopus.Chemicals and CAS Registry Numbers: amino acid, 65072-01-7; ciprofloxacin, 85721-33-1; DNA topoisomerase (ATP hydrolysing); gatifloxacin, 112811-59-3, 180200-66-2; levofloxacin, 100986-85-4, 138199-71-0; lomefloxacin, 98079-51-7 ...
Davila, C., Llach, L., Ramirez-Tagle, R., Salgado-Moran, G.   +3 more
core  

Maintenance of Microbial Cooperation Mediated by Public Goods in Single- and Multiple-Trait Scenarios [PDF]

, 2017
Microbes often form densely populated communities, which favor competitive and cooperative interactions. Cooperation among bacteria often occurs through the production of metabolically costly molecules produced by certain individuals that become ...
Balbontín, Roberto, Dionisio, Francisco, Xavier, Karina Bivar, Özkaya, Özhan   +3 more
core   +1 more source