Results 111 to 120 of about 94,885 (205)

A retrospective study of the efficacy and safety of levofloxacin in children with severe infection

Frontiers in Pediatrics
ObjectivesLevofloxacin is widely used because of its broad-spectrum antimicrobial activity and convenient dosing schedule. However, the relevance of its use in children remains to be investigated.
Zhang Junqi, Cai Jie, Wang Jinglin, Lu Jinmiao, Lu Guoping, Wang Yi, Li Zhiping   +6 more
doaj   +1 more source

Estimating the Effects of Global Patent Protection in Pharmaceuticals: A Case Study of Quinolones in India [PDF]

Under the TRIPS agreement, WTO members are required to enforce product patents for pharmaceuticals. The debate about the merits of this requirement has been extremely contentious. Many low income economies claim that patent protection for pharmaceuticals
Panle Jia, Pinelopi K. Goldberg, Shubham Chaudhuri   +2 more
core  

Synergistic Effects of IMP‐1700, Ciprofloxacin, and X‐Ray Radiation in Bacteria and Mammalian Cell Lines: Implications for Use in Antimicrobial‐Resistant Bacteria

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
IMP‐1700 enhances the cytotoxic effect on bacteria in combination with either ciprofloxacin (CPX) or X‐ray. In noncancerous and tumor cells, combination treatments markedly reduce viability with radiosensitizing effects. Further studies are needed to clarify the mechanism underlying IMP‐1700s effects on mammalian cells. Created in BioRender. Kjaer, A. (
Ida Vang Andersen, Ane Beth Sloth, Emilie Caroline Skuladottir Bøgestad, Christian Bernard Matthijs Poulie, Anne Skovsbo Clausen, Umberto Maria Battisti, Matthias M. Herth, Andreas Kjaer   +7 more
wiley   +1 more source

Genomic characterization of antibiotic resistant Escherichia coli isolated from domestic chickens in Pakistan [PDF]

, 2019
Poultry husbandry is important for the economic health of Pakistan, but the Pakistani poultry industry is negatively impacted by infections ...
Abbas, Muhammad Athar, Ali Malik, Akbar, Ali, Naeem, Burnham, Carey-Ann D, D\u27Souza, Alaric W, Dantas, Gautam, Ferreiro, Aura, Potter, Robert F, Rafique, Muhammad, Rahim, Abdul, Siddique, Naila, Wallace, Meghan A   +11 more
core   +1 more source

Medicare Part D and Hospital Admissions due to Antimicrobial Resistance

Health Economics, Volume 35, Issue 5, Page 759-777, May 2026.
ABSTRACT Antimicrobial resistance (AMR) has been increasing rapidly in the United States despite government efforts to contain its spread. Both under‐utilization and overuse of prescribed antimicrobials contribute to rising resistance. The introduction of Medicare Part D in 2006 expanded prescription drug coverage for the elderly, including coverage ...
Ricardo B. Ang III
wiley   +1 more source

Advances in immunoassay methods for quinolones

Shipin yu jixie
Quinolones (QNs) are highly favored for their broad-spectrum antibacterial effects. However, the overuse of QNs in animal feed can lead to their residues entering the food chain, thus posing potential hazards to the environment and human health.
WU Mengjiao, LI Ning, HU Mei, XU Yan, WANG Jie, XIANG Feng   +5 more
doaj   +1 more source

An integrated social and natural sciences case study for the reuse of organic wastes as soil amendments

PLANTS, PEOPLE, PLANET, Volume 8, Issue 3, Page 965-982, May 2026.
Reusing organic waste materials, such as animal manure, as soil amendments reduces water and fertiliser demand, contributing to achieving the Sustainable Development Goals. However, organic wastes may contain contaminants of emerging concern (CECs), posing potential ecosystem and human health risks. Despite the importance of this issue, there is a lack
Felicity C. T. Elder, Jose‐Luis Fajardo‐Escoffié, Laura Carter, Emily K. Durant, Katie J. Field, John Nightingale, Brett Sallach, Andrea‐Lorena Garduño‐Jiménez   +7 more
wiley   +1 more source

WQ-3810, a fluoroquinolone with difluoropyridine derivative as the R1 group exerts high potency against quinolone-resistant Campylobacter jejuni

Microbiology Spectrum
Quinolone-resistant Campylobacter jejuni have been increasing worldwide. Quinolones exert their antibacterial activity by inhibiting DNA gyrase, but most of the isolates acquire quinolone resistance via an amino acid substitution in the A subunit of DNA ...
Kentaro Koide, Hyun Kim, Matthew V. X. Whelan, Lawrence P. Belotindos, Wimonrat Tanomsridachchai, Ruchirada Changkwanyeun, Masaru Usui, Tadhg Ó Cróinín, Jeewan Thapa, Chie Nakajima, Yasuhiko Suzuki   +10 more
doaj   +1 more source

Pathogenicity and Antimicrobial‐Resistance Profiles of Escherichia coli Isolated From Faeces of Tibetan Pigs Reared Under Intensive Conditions

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
Tibetan pig farms host diverse Escherichia coli strains that resist multiple antibiotics and carry important disease genes, such as astA. These traits jump easily between bacterial groups, marking intensive pig production as a key reservoir and signalling the need for integrated animal–human surveillance and more careful antibiotic use.
Runbo Luo, Lihong Zhang, Kexin Li, Yanan Zhong, Peng Shang, Suolang Sizhu, Md. F. Kulyar, Ruibing Cao   +7 more
wiley   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, Volume 14, Issue 4, Page 978-991, May 2026.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source