Results 191 to 200 of about 71,327 (249)
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Medical Clinics of North America, 1995
Fluoroquinolones represent a major advance in antimicrobial chemotherapy. Currently, there are five fluoroquinolones approved by the FDA, and many more quinolones are expected to become available in years to come. Although their clinical utility is constantly expanding, they have been best studied in complicated urinary tract infections, chronic ...
B, Suh, B, Lorber
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Fluoroquinolones represent a major advance in antimicrobial chemotherapy. Currently, there are five fluoroquinolones approved by the FDA, and many more quinolones are expected to become available in years to come. Although their clinical utility is constantly expanding, they have been best studied in complicated urinary tract infections, chronic ...
B, Suh, B, Lorber
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Urological Research, 1989
The new quinolones have broad antimicrobial spectra covering all aerobic gram-negative and gram-positive bacteria encountered in urinary tract infections. All are administered orally, some also parenterally, low degree of resistance, few side effects and bacteriological and clinical cure rates similar to or higher than traditional antimicrobials make ...
K T, Nielsen, P O, Madsen
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The new quinolones have broad antimicrobial spectra covering all aerobic gram-negative and gram-positive bacteria encountered in urinary tract infections. All are administered orally, some also parenterally, low degree of resistance, few side effects and bacteriological and clinical cure rates similar to or higher than traditional antimicrobials make ...
K T, Nielsen, P O, Madsen
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Pacing and Clinical Electrophysiology, 2003
Quinolones block the rapid component of the delayed rectifier potassium current (Ik) in a dose dependent manner. This electrophysiological action translates into prolongation of the QT interval and may predispose to development of torsades de pointes. QT prolongation appears to be a class effect but there is a wide range of potency among class members.
Demosthenes, Katritsis, A John, Camm
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Quinolones block the rapid component of the delayed rectifier potassium current (Ik) in a dose dependent manner. This electrophysiological action translates into prolongation of the QT interval and may predispose to development of torsades de pointes. QT prolongation appears to be a class effect but there is a wide range of potency among class members.
Demosthenes, Katritsis, A John, Camm
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Drugs, 1999
Reactions of the gastrointestinal tract, the CNS and the skin are the most often observed adverse effects during therapy with fluoroquinolones. At least for some of the newer fluoroquinolones a steep dose-response relationship of adverse effects seems to exist. Pathogenesis of the neurotoxic effects of fluoroquinolones is still unknown. Among the newer
R, Stahlmann, H, Lode
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Reactions of the gastrointestinal tract, the CNS and the skin are the most often observed adverse effects during therapy with fluoroquinolones. At least for some of the newer fluoroquinolones a steep dose-response relationship of adverse effects seems to exist. Pathogenesis of the neurotoxic effects of fluoroquinolones is still unknown. Among the newer
R, Stahlmann, H, Lode
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Infectious Disease Clinics of North America, 1989
The molecular basis of activity, chemistry, microbiology, and pharmacology of the new fluoroquinolones is reviewed in this article. Areas of clinical use are analyzed with specific reference to efficacy, development of resistance, and potential for toxicity.
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The molecular basis of activity, chemistry, microbiology, and pharmacology of the new fluoroquinolones is reviewed in this article. Areas of clinical use are analyzed with specific reference to efficacy, development of resistance, and potential for toxicity.
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New cytotoxic quinolone alkaloids from fruits of Evodia rutaecarpa
Fìtoterapìâ, 2012 Three new quinolone alkaloids, 1-methyl-2-[7-hydroxy-(E)-9-tridecenyl]-4(1H)-quinolone (1), 1-methyl-2-[(Z)-4-nonenyl]-4(1H)-quinolone (2), 1-methyl-2-[(1E,5Z)-1,5-undecadienyl]-4(1H)-quinolone (3) and one new natural product, 1-methyl-2-[(E)-1-undecenyl]
Xiu-Wei Yang
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Drugs, 1995
Aging results in a number of physiological changes that can affect drug disposition; these include reduced gastric acidity, decreased intestinal motility, lower lean body mass, and reduction in renal function. The age-related decline in renal function is the most important of these factors when administering quinolones to elderly patients.
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Aging results in a number of physiological changes that can affect drug disposition; these include reduced gastric acidity, decreased intestinal motility, lower lean body mass, and reduction in renal function. The age-related decline in renal function is the most important of these factors when administering quinolones to elderly patients.
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Clinics in Dermatology, 2003
T he quinolones are an important class of broad-spectrum antimicrobials in common use today. Multiple quinolones are currently available in the United States (Table 1) with broader spectrums and longer half-lives than older quinolones, such as nalidixic acid (Fig 1A).
David, Sable, George J, Murakawa
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T he quinolones are an important class of broad-spectrum antimicrobials in common use today. Multiple quinolones are currently available in the United States (Table 1) with broader spectrums and longer half-lives than older quinolones, such as nalidixic acid (Fig 1A).
David, Sable, George J, Murakawa
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Drugs, 1993
This review emphasises the advances in the development of newer quinolones: their broader antimicrobial activity particularly their increased activity against Pneumococcus and anaerobes; their longer half-life and tissue penetration including activity in cerebrospinal fluid; and their excellent efficacy in respiratory, intra-abdominal, pelvic, and skin
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This review emphasises the advances in the development of newer quinolones: their broader antimicrobial activity particularly their increased activity against Pneumococcus and anaerobes; their longer half-life and tissue penetration including activity in cerebrospinal fluid; and their excellent efficacy in respiratory, intra-abdominal, pelvic, and skin
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Current Pharmaceutical Design, 1970
Abstract: Following the discovery of nalidixic acid in 1962, numerous structural modifications have been made to the quinolone nucleus to increase antimicrobial activit> and improve pharmacokinetic performance. A major advance occured during the 1980\ with the discovery that a fluorine at position-6 conferred broad and potent antimicrobial activity,
M, Kidwai, P, Misra, R, Kumar
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Abstract: Following the discovery of nalidixic acid in 1962, numerous structural modifications have been made to the quinolone nucleus to increase antimicrobial activit> and improve pharmacokinetic performance. A major advance occured during the 1980\ with the discovery that a fluorine at position-6 conferred broad and potent antimicrobial activity,
M, Kidwai, P, Misra, R, Kumar
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