Results 81 to 90 of about 103,486 (339)

The Antibiotic Resistance Pattern of Gram-Negative Bacteria in Children Younger Than 24 Months with a Urinary Tract Infection: A Retrospective Single-Center Study over 15 Consecutive Years [PDF]

Childhood Kidney Diseases, 2015
Purpose: We investigated trends in antibiotic resistance for gram-negative bacteria in infants with a urinary tract infection (UTI) over 15 years at a single institution.
Yoon Kyoung Lee, Haejeong Lee, Jong Min Kim, Ji-Man Kang, Sang Taek Lee, Nam Yong Lee, Yae-Jean Kim, Heeyeon Cho   +7 more
doaj   +1 more source

Quantitative Risk Assessment of Susceptible and Ciprofloxacin-Resistant Salmonella from Retail Pork in Chiang Mai Province in Northern Thailand

Foods, 2022
The adverse human health effects as a result of antimicrobial resistance have been recognized worldwide. Salmonella is a leading cause of foodborne illnesses while antimicrobial resistant (AMR) Salmonella has been isolated from foods of animal origin ...
Chaiwat Pulsrikarn, Anusak Kedsin, Parichart Boueroy, Peechanika Chopjitt, Rujirat Hatrongjit, Piyarat Chansiripornchai, Nipattra Suanpairintr, Suphachai Nuanualsuwan   +7 more
doaj   +1 more source

Complexation of norfloxacin with DNA in the presence of caffeine [PDF]

, 2006
1H NMR spectroscopy (500 MHz) has been used to quantify the complexation of the antibacterial antibiotic Norfloxacin (NOR) with DNA in the presence of Caffeine (CAF). Separate studies have been made for the self-association of NOR, its hetero-association
Davies, David B., Evstigneev, M.P., Rybakova, K.A.   +2 more
core   +1 more source

Safety of sulfamethoxazole–trimethoprim for the treatment of bacterial infection in outpatient settings: A systematic review and meta‐analysis with active comparator disproportionality analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Sulfamethoxazole–trimethoprim (SMX‐TMP) is a widely used antibiotic for treating bacterial infections, but its safety in adult outpatients remains understudied. This systematic review and meta‐analysis evaluated the safety profile of SMX‐TMP and identified critical research gaps.
Rebecca Preyra, Lujain Ez Eddin, Fatemeh Ahmadi, Atefeh Jafari, Flory T. Muanda   +4 more
wiley   +1 more source

Discovery of (S)-3′-hydroxyblebbistatin and (S)-3′-aminoblebbistatin : polar myosin II inhibitors with superior research tool properties [PDF]

, 2017
In search of myosin II inhibitors with superior research tool properties, a chemical optimization campaign of the blebbistatin scaffold was conducted in this paper. (S)-Blebbistatin is the best known small-molecule inhibitor of myosin II ATPase activity.
Bracke, Marc, De Wever, Olivier, Roman, Bart, Stevens, Christian, Van Deun, Rik, Van Hecke, Kristof, Verhasselt, Sigrid   +6 more
core   +1 more source

Chemical structure and pharmacokinetics of novel quinolone agents represented by avarofloxacin, delafloxacin, finafloxacin, zabofloxacin and nemonoxacin

Annals of Clinical Microbiology and Antimicrobials, 2016
Quinolones are potent antimicrobial agents with a basic chemical structure of bicyclic ring. Fluorine atom at position C-6 and various substitutions on the basic quinolone structure yielded fluoroquinolones, namely norfloxacin, ciprofloxacin ...
B. Kocsis, J. Domokos, D. Szabo
semanticscholar   +1 more source

Pharmacokinetics and Safety Evaluation of a New Generic Sitafloxacin: A Phase I Bioequivalence Study in Healthy Chinese Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Sitafloxacin is a new antibiotic drug belonging to the fourth generation quinolone antibiotics. The aim of this study was to evaluate the pharmacokinetics (PK), safety profiles, and bioequivalence of test and reference 50‐mg sitafloxacin tablets under fasting and fed conditions.
Yongfang Lei, Pan Luo, Yuzhu Chen, Liuliang Xue, Donglin Zhang, Xingxing Qi, Yinian Fang, Hengyi Yu, Zheng He, Qin Zuo, Chang Liu, Dong Liu, Xinhua Ren, Qian Chen   +13 more
wiley   +1 more source

Enzymatic one-step ring contraction for quinolone biosynthesis. [PDF]

, 2018
The 6,6-quinolone scaffolds on which viridicatin-type fungal alkaloids are built are frequently found in metabolites that display useful biological activities.
Champagne, Pier Alexandre, Hara, Kodai, Hashimoto, Hiroshi, Hirayama, Yuichiro, Houk, Kendall N, Kishimoto, Shinji, Tang, Yi, Watanabe, Kenji   +7 more
core  

Shigella sonnei genome sequencing and phylogenetic analysis indicate recent global dissemination from Europe [PDF]

, 2012
Shigella are human-adapted Escherichia coli that have gained the ability to invade the human gut mucosa and cause dysentery1,2, spreading efficiently via low-dose fecal-oral transmission3,4. Historically, S.
A Mutreja, A Nastasi, A Saeed, A Stamatakis, AJ Drummond, Andrew Kitchen, D Cohen, D Genobile, DA Sack, Derek J Brown, Derek J Pickard, DK Karaolis, Dong Wook Kim, DR Zerbino, E Paradis, Edward C Holmes, F Yang, François-Xavier Weill, G Greub, G Morelli, GM Pupo, Gordon Dougan, H Li, H Li, H Vinh, H Vinh, H Vinh, HC Lewis, HJ Jeong, HL DuPont, J Parker, J Tang, J Winiecka-Krusnell, Jeremy J Farrar, JG Shepherd, John E Coia, Julian Parkhill, Jun Yu, Kathryn E Holt, KE Holt, KL Kotloff, LL Van de Verg, M Touchon, Nicholas R Thomson, PJ Sansonetti, R Ranjbar, RK Aziz, RW Kaminski, S Kurtz, Seon Young Choi, SR Harris, Stephen Baker, Su Hee Kim, T Shimada, Vartul Sangal, Wanderley D da Silveira   +55 more
core   +3 more sources

Origins of the Quinolone Class of Antibacterials: An Expanded "Discovery Story".

Journal of Medicinal Chemistry, 2015
Published descriptions of the specific lines of research leading to the discovery of therapeutically important medicines, especially major new class medicines, have long provided value to the biopharmaceutical community as models of success, often ...
G. Bisacchi
semanticscholar   +1 more source