Results 81 to 90 of about 75,013 (302)

Substrate Epoxidation Catalyzed by the Nonheme Iron Dioxygenase Dapdiamide Biosynthesis Enzyme C. Why Is the Substrate Tethered?

Chemistry – A European Journal, EarlyView.
In this work a computational study shows the differences in binding and catalysis of a nonheme iron oxygenase with tethered versus nontethered substrate. The tethered substrate is positioned in an ideal orientation near the active site, while the nontethered substrate shows more dynamics and is not positioned well for double bond epoxidation.
Jingyu Cao, Sam P. de Visser
wiley   +1 more source

Actinobacillus pleuropneumoniae Eradication with Enrofloxacin May Lead to Dissemination and Long-Term Persistence of Quinolone Resistant Escherichia coli in Pig Herds

Antibiotics, 2020
Norway has a favourable situation with regard to health status and antimicrobial usage in the pig production sector. However, one of the major disease-causing agents in the commercial pig population is Actinobacillus pleuropneumoniae (APP). In some herds,
Håkon Kaspersen, Anne Margrete Urdahl, Carl Andreas Grøntvedt, Stine Margrethe Gulliksen, Bereket Tesfamichael, Jannice Schau Slettemeås, Madelaine Norström, Camilla Sekse   +7 more
doaj   +1 more source

Lanthanum triflate triggered synthesis of tetrahydroquinazolinone derivatives of N-allyl quinolone and their biological assessment [PDF]

Journal of the Serbian Chemical Society, 2012
A series of 24 derivatives of tetrahydroquinazolinone has been synthesized by one-pot cyclocondensation reaction of N-allyl quinolones, cyclic β-diketones and (thio)urea/N-phenylthiourea in presence of lanthanum triflate catalyst.
Jardosh Hardik H., Patel Manish P.
doaj   +1 more source

Transition Metal Carbide‐Based Catalysis for Thermocatalytic Conversion Processes: Properties, Synthesis, Applications, and Future Outlook

ChemNanoMat, EarlyView.
Transition metal carbides (TMCs) have electronic structure similar to that of platinum group metals, making them attractive for thermocatalysis applications. This review explores several essential aspects, discussing physical and chemical properties of TMCs, synthesis methods, and their utilization in thermocatalytic processes, including generation of ...
Edris Madadian, Yasaman Ghaffari, Yael Zilberman, David S. A. Simakov   +3 more
wiley   +1 more source

Risk of Infections with SGLT2 Inhibitors Versus DPP4 Inhibitors: A Population‐Based Cohort Study Using Antibiotic Dispensing Data

Clinical Pharmacology &Therapeutics, EarlyView.
This study compared the number and cumulative dose of antibiotic dispensings among new users of sodium–glucose cotransporter‐2 (SGLT2) inhibitors and dipeptidyl peptidase‐4 (DPP4) inhibitors following hospital discharge in individuals with type 2 diabetes.
Maria J. Alfonso Arvez, George S. Q. Tan, Sam Wade, Zanfina Ademi, Jenni Ilomäki, J. Simon Bell   +5 more
wiley   +1 more source

Plasmid-mediated quinolone resistance; interactions between human, animal and environmental ecologies

Frontiers in Microbiology, 2012
Resistance to quinolones and fluoroquinolones is being increasingly reported among human but also veterinary isolates during the last two to three decades, very likely as a consequence of the large clinical usage of those antibiotics.
Laurent ePOIREL, Vincent eCattoir, Patrice eNordmann   +2 more
doaj   +1 more source

Mining Public Mass Spectrometry Data to Characterize the Diversity and Ubiquity of P. aeruginosa Specialized Metabolites

Metabolites, 2020
Pseudomonas aeruginosa is a ubiquitous environmental bacterium that causes chronic infections of burn wounds and in the lungs of cystic fibrosis (CF) patients.
Andrew C. Lybbert, Justin L. Williams, Ruma Raghuvanshi, A. Daniel Jones, Robert A. Quinn   +4 more
doaj   +1 more source

Insights into the Base‐Stabilized Silylene Nature of the IrSi Bond in Ir(III)–(κ2‐NSi) Complexes with 2‐Quinolone and 2‐Pyridone Type Ligands

European Journal of Inorganic Chemistry, EarlyView.
Density functional theory calculations (natural bond orbital and quantum theory of atoms in molecules analyses) on Ir–(κ2‐NSi) complexes with 2‐quinolone and 2‐pyridone derived ligands indicate that the bond is best described as a base‐stabilized silylene. The silicon environment is the key for determining the nature of the IrSi bond.
Marina Padilla, María Batuecas, Pilar García‐Orduña, Luis A. Oro, Francisco José Fernández‐Alvarez   +4 more
wiley   +1 more source

A retrospective study of the efficacy and safety of levofloxacin in children with severe infection

Frontiers in Pediatrics
ObjectivesLevofloxacin is widely used because of its broad-spectrum antimicrobial activity and convenient dosing schedule. However, the relevance of its use in children remains to be investigated.
Zhang Junqi, Cai Jie, Wang Jinglin, Lu Jinmiao, Lu Guoping, Wang Yi, Li Zhiping   +6 more
doaj   +1 more source

Rare-Earth Metal Complexes of the Antibacterial Drug Oxolinic Acid: Synthesis, Characterization, DNA/Protein Binding and Cytotoxicity Studies

Molecules, 2020
“Drug repositioning” is a current trend which proved useful in the search for new applications for existing, failed, no longer in use or abandoned drugs, particularly when addressing issues such as bacterial or cancer cells resistance to current ...
Ana-Madalina Maciuca, Alexandra-Cristina Munteanu, Mirela Mihaila, Mihaela Badea, Rodica Olar, George Mihai Nitulescu, Cristian V. A. Munteanu, Marinela Bostan, Valentina Uivarosi   +8 more
doaj   +1 more source