Results 151 to 160 of about 34,906 (202)
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Drugs, 1993
This review emphasises the advances in the development of newer quinolones: their broader antimicrobial activity particularly their increased activity against Pneumococcus and anaerobes; their longer half-life and tissue penetration including activity in cerebrospinal fluid; and their excellent efficacy in respiratory, intra-abdominal, pelvic, and skin
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This review emphasises the advances in the development of newer quinolones: their broader antimicrobial activity particularly their increased activity against Pneumococcus and anaerobes; their longer half-life and tissue penetration including activity in cerebrospinal fluid; and their excellent efficacy in respiratory, intra-abdominal, pelvic, and skin
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Clinical Pharmacokinetics, 1992
The fluoroquinolones represent a relatively new class of antibiotics with outstanding therapeutic potential, attributable to their broad spectrum of antimicrobial activity and favourable tissue distribution. They are highly active against most Gram-negative pathogens, as well as Staphylococcus aureus and coagulase-negative staphylococci.
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The fluoroquinolones represent a relatively new class of antibiotics with outstanding therapeutic potential, attributable to their broad spectrum of antimicrobial activity and favourable tissue distribution. They are highly active against most Gram-negative pathogens, as well as Staphylococcus aureus and coagulase-negative staphylococci.
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Pharmaceutisch Weekblad Scientific Edition, 1986
The quinolones are synthetic antibiotics chemically related to nalidixic acid. Since its introduction, several structural analogues have been synthesized. A fundamental breakthrough was the addition of a fluorine atom. The quinolones interfere with bacterial DNA transcription by inhibiting the enzyme DNA gyrase, that so far has only been found in ...
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The quinolones are synthetic antibiotics chemically related to nalidixic acid. Since its introduction, several structural analogues have been synthesized. A fundamental breakthrough was the addition of a fluorine atom. The quinolones interfere with bacterial DNA transcription by inhibiting the enzyme DNA gyrase, that so far has only been found in ...
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Current Pharmaceutical Design, 1970
Abstract: Following the discovery of nalidixic acid in 1962, numerous structural modifications have been made to the quinolone nucleus to increase antimicrobial activit> and improve pharmacokinetic performance. A major advance occured during the 1980\ with the discovery that a fluorine at position-6 conferred broad and potent antimicrobial activity,
M, Kidwai, P, Misra, R, Kumar
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Abstract: Following the discovery of nalidixic acid in 1962, numerous structural modifications have been made to the quinolone nucleus to increase antimicrobial activit> and improve pharmacokinetic performance. A major advance occured during the 1980\ with the discovery that a fluorine at position-6 conferred broad and potent antimicrobial activity,
M, Kidwai, P, Misra, R, Kumar
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Current Opinion in Allergy and Clinical Immunology, 2003
Quinolones are potent antibacterial agents that can cause drug hypersensitivity reactions affecting different organs. A better understanding of the underlying mechanism and the level of crossreactivity within different quinolones is needed to handle and prevent these diseases.The adverse side-effects caused by quinolones are the result of different ...
Paolo, Campi, Werner J, Pichler
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Quinolones are potent antibacterial agents that can cause drug hypersensitivity reactions affecting different organs. A better understanding of the underlying mechanism and the level of crossreactivity within different quinolones is needed to handle and prevent these diseases.The adverse side-effects caused by quinolones are the result of different ...
Paolo, Campi, Werner J, Pichler
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Journal of Antimicrobial Chemotherapy, 1990
Fluoroquinolones have been in use for the past five years. The agents inhibit Enterobacteriaceae, Pseudomonas aeruginosa, and staphylococci, but some agents lack activity against streptococci and none of the commercially available agents inhibits anaerobic species.
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Fluoroquinolones have been in use for the past five years. The agents inhibit Enterobacteriaceae, Pseudomonas aeruginosa, and staphylococci, but some agents lack activity against streptococci and none of the commercially available agents inhibits anaerobic species.
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International Journal of Antimicrobial Agents, 1992
Fluoroquinolones have broad antibacterial spectra and are active against most Gram-negative and many Gram-positive species. They exhibit excellent oral bioavailability, extensive tissue penetration, low protein binding, and a long elimination half-life.
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Fluoroquinolones have broad antibacterial spectra and are active against most Gram-negative and many Gram-positive species. They exhibit excellent oral bioavailability, extensive tissue penetration, low protein binding, and a long elimination half-life.
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2003
Quinolone antibacterial agents were first introduced into the clinical environment in the early 1960s. The first qumolone to be clinically used was nalidixic acid, which was used for the treatment of enteric and urinary tract infections. As a result of increased clinical resistance to this drug, its use has declined.
J C, Brown, S G, Amyes
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Quinolone antibacterial agents were first introduced into the clinical environment in the early 1960s. The first qumolone to be clinically used was nalidixic acid, which was used for the treatment of enteric and urinary tract infections. As a result of increased clinical resistance to this drug, its use has declined.
J C, Brown, S G, Amyes
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Obstetrics and Gynecology Clinics of North America, 1992
The fluorinated quinolones are synthetic derivatives of nalidixic acid. They are well absorbed when administered orally and have an extended duration of action. They are of primary value in treating gonorrhea and complicated urinary tract infections in nonpregnant women.
K, Saravanos, P, Duff
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The fluorinated quinolones are synthetic derivatives of nalidixic acid. They are well absorbed when administered orally and have an extended duration of action. They are of primary value in treating gonorrhea and complicated urinary tract infections in nonpregnant women.
K, Saravanos, P, Duff
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Hypersensitivity Reactions to Quinolones
Current Pharmaceutical Design, 2006Quinolones are one of the most important classes of antimicrobial agents discovered in the recent years and one of the most widely used classes of antibiotics in clinical medicine. Their broad spectrum of activity and pharmacokinetic properties make them ideal agents for treating a variety of infections.
Schmid, Daphné Anne +2 more
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