Results 51 to 60 of about 101,168 (296)

Usual and unusual antibacterial effects of quinolones [PDF]

, 2017
Recently documented antibacterial effects of quinolones are reviewed. DNA gyrase is most likely to be the primary target site for these agents. Quinolones rapidly kill susceptible bacteria; the mechanisms of the bactericidal activity, still poorly ...
Furet, Y. X., Pechère, J.-C
core  

Cost-effectiveness of management strategies for acute urethritis in the developing world. [PDF]

, 2000
OBJECTIVE: To recommend a cost-effective approach for the management of acute male urethritis in the developing world, based on the findings of a theoretical study.
Crabbé, F, de Clerck, M, Laga, M, Vuylsteke, B   +3 more
core   +2 more sources

The regioselective iodination of quinolines, quinolones, pyridones, pyridines and uracil.

Chemical Communications, 2015
A radical based direct C-H iodination protocol for quinolines, quinolones, pyridones, pyridines, and uracil has been developed. The iodination occurs in a C3 selective manner for quinolines and quinolones.
U. Dutta, Arghya Deb, D. Lupton, D. Maiti   +3 more
semanticscholar   +1 more source

Antibacterial and Antibiofilm Activity of 8‐Hydroxyquinoline Derivatives Against Mycobacterium and Staphylococcus Species

Chemistry &Biodiversity, EarlyView.
Synthesis of 8‐hydroxyquinoline derivatives (QD 1‐12) from different analogues of 8‐hydroxyquinoline (HQ 1‐4). The derivatives and parent compounds were evaluated for antibacterial and antibiofilm activity against Mycobacterium tuberculosis, Mycobacterium smegmatis, methicillin‐resistant Staphylococcus aureus and methicillin‐sensitive Staphylococcus ...
Namrita Lall, Anna‐Mari Kok, Carel B. Oosthuizen, Surjeet Verma, François Chassagne, Phuc H. Vo, Khanh‐Van Ho, Chung‐Ho Lin, Cassandra L. Quave, Danielle Twilley   +9 more
wiley   +1 more source

Europe's contribution to the evaluation of the use of systemic antimicrobials in the treatment of periodontitis

Periodontology 2000, EarlyView., 2023
Abstract This narrative review celebrates Europe's contribution to the current knowledge on systemically administered antimicrobials in periodontal treatment. Periodontitis is the most frequent chronic noncommunicable human disease. It is caused by dysbiotic bacterial biofilms and is commonly treated with subgingival instrumentation.
David Herrera, Arie Jan van Winkelhoff, Paula Matesanz, Katalina Lauwens, Wim Teughels   +4 more
wiley   +1 more source

Consumption of antibiotics at St Luke’s Hospital : a critical factor behind the local prevalence of antimicrobial resistance? [PDF]

, 2006
The intensity of antibiotic use in hospital settings is recognised as possibly the most important factor for the selection of antimicrobial resistance. Hospitals are therefore being encouraged to undertake surveillance and benchmarking of antimicrobial ...
Borg, Michael Angelo, Zarb, Peter
core  

Development of Bone Targeting Drugs. [PDF]

, 2017
The skeletal system, comprising bones, ligaments, cartilage and their connective tissues, is critical for the structure and support of the body. Diseases that affect the skeletal system can be difficult to treat, mainly because of the avascular cartilage
Alméciga-Díaz, Carlos J., Mackenzie, William G., Mason, Robert W., Orii, Tadao, Sawamoto, Kazuki, Stapleton, Molly, Tomatsu, Shunji   +6 more
core   +2 more sources

Sequential Carboborylation–Suzuki Coupling of α,β‐Unsaturated Tosylhydrazones: A Dual CC Bond‐Forming Strategy for Molecular Diversification

ChemistryEurope, EarlyView.
Structural diversity can be generated from α,β‐unsaturated carbonyls via N‐tosylhydrazones through a one‐pot‐three‐component photochemically promoted carboborylation/allylic Suzuki sequence. The wide availability and scope regarding each of three reaction partners: carbonyls, alkylboronic acids, and aryl halides, and the functionalities available in ...
Álvaro Valdés‐Maqueda, Manuel Plaza, Carlos Valdés   +2 more
wiley   +1 more source

Supra and subgingival application of antiseptics or antibiotics during periodontal therapy

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases (gingivitis and periodontitis) are characterized by inflammatory processes which arise as a result of disruption of the balance in the oral ecosystem. According to the current S3 level clinical practice guidelines, therapy of patients with periodontitis involves a stepwise approach that includes the control of the patient ...
Elena Figuero, Jorge Serrano, Nicole Birgit Arweiler, Thorsten Mathias Auschill, Ali Gürkan, Gülnur Emingil   +5 more
wiley   +1 more source

Intepirdine Derivatives Possessing Dual 5HT6 Antagonism / HDAC6 Inhibitory Activity

Chemistry – A European Journal, EarlyView.
In the context of developing therapies for dementias and cognitive decline, potent dual acting molecules targeting the GPCR 5HT6 and the enzyme HDAC6 with favorable BBB penetration profile were designed and synthesised. Abstract Alzheimer's Disease (AD) impacts significantly the quality of life of people aged over 65 years old, while millions more ...
Andreas Gkanas, Maria Koutiva, Theodora Katsila, Vivi Bafiti, Minos‐Timotheos Matsoukas, Vasilios Panagiotopoulos, Andrzej J. Bojarski, Theodoros Gkouvitsas, Georgios Moukas, Gerasimos Rassias   +9 more
wiley   +1 more source