Results 31 to 40 of about 34,733 (170)

Quinolones-Induced Musculoskeletal, Neurological, and Psychiatric ADRs: A Pharmacovigilance Study Based on Data From the Italian Spontaneous Reporting System

Frontiers in Pharmacology, 2020
BackgroundThe use of quinolones has been associated with the development of serious and persistent adverse drug reaction (ADR) mainly affecting muscles, joints and the nervous system.
Cristina Scavone, Cristina Scavone, Annamaria Mascolo, Annamaria Mascolo, Rosanna Ruggiero, Rosanna Ruggiero, Liberata Sportiello, Liberata Sportiello, Concetta Rafaniello, Concetta Rafaniello, Liberato Berrino, Annalisa Capuano, Annalisa Capuano   +12 more
doaj   +1 more source

Synthesis of Quinolones and Zwitterionic Quinolonate Derivatives with Broad-Spectrum Antibiotic Activity

Pharmaceuticals, 2022
Quinolones are one of the most extensively used therapeutic families of antibiotics. However, the increase in antibiotic-resistant bacteria has rendered many of the available compounds useless.
Beatriz Suay-García, Jose-Ignacio Bueso-Bordils, Gerardo Antón-Fos, María-Teresa Pérez-Gracia, Antonio Falcó, Pedro Alemán-López   +5 more
doaj   +1 more source

Analytical methods for the determination of some selected 4-quinolone antibacterials

Reviews in Analytical Chemistry, 2017
A comprehensive review with 337 references for the analysis of some selected 4-quinolone drugs belonging to the first and second generations since 2006 up till now is presented. This group includes nalidixic acid, oxolinic acid, piromidic acid, pipemidic
Belal Fathallah, El-Enany Nahed, Wahba Mary E.K.   +2 more
doaj   +1 more source

Rapid Phenotypic Convergence towards Collateral Sensitivity in Clinical Isolates of Pseudomonas aeruginosa Presenting Different Genomic Backgrounds

Microbiology Spectrum, 2023
Collateral sensitivity (CS) is an evolutionary trade-off by which acquisition of resistance to an antibiotic leads to increased susceptibility to another.
Sara Hernando-Amado, Carla López-Causapé, Pablo Laborda, Fernando Sanz-García, Antonio Oliver, José Luis Martínez   +5 more
doaj   +1 more source

Anticancer Activity of Some Ruthenium(III) Complexes with Quinolone Antibiotics: In Vitro Cytotoxicity, Cell Cycle Modulation, and Apoptosis-Inducing Properties in LoVo Colon Cancer Cell Line

Applied Sciences, 2021
Cisplatin is one of the most effective anticancer agents used to treat colon cancer, which is the third malignancy between the most common human cancers in the world, but the resistance developed represents an obstacle against the full success of ...
Mirela Mihaila, Camelia Mia Hotnog, Marinela Bostan, Alexandra Cristina Munteanu, Ileana Adela Vacaroiu, Lorelei Irina Brasoveanu, Valentina Uivarosi   +6 more
doaj   +1 more source

Docking studies on novel analogs of quinolones against DNA gyrase of Escherichia coli [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2018
Context: Bacterial resistance to antibiotics is the inevitable consequence of the use of antimicrobial agents. Thus, quinolones are an important class of antibacterials; these agents generally consist of a 1-subtituted-1,4-dihydro-4-oxopyridine-3 ...
Cristian Davila, Lorena Llach, Guillermo Salgado-Moran, Rodrigo Ramirez-Tagle   +3 more
doaj  

The First Saudi Report of Novel and Common Mutations in the gyrA and parC Genes Among Pseudomonas Spp. Clinical Isolates Recovered from Taif Area

Infection and Drug Resistance, 2022
Mohamed F El-Badawy,1,* Emad M Eed,2,* Asmaa S Sleem,3 Azza AK El-Sheikh,4 Ibrahim A Maghrabi,5 Sayed F Abdelwahab6 1Department of Microbiology and Immunology, Faculty of Pharmacy, University of Sadat City, Sadat City, Menoufia, 32897, Egypt ...
El-Badawy MF, Eed EM, Sleem AS, El-Sheikh AAK, Maghrabi IA, Abdelwahab SF   +5 more
doaj  

Synthesis and biological activity of methylated derivatives of the Pseudomonas metabolites HHQ, HQNO and PQS

Beilstein Journal of Organic Chemistry, 2019
Selectively methylated analogues of naturally occurring 2-heptyl-4(1H)-quinolones, which are alkaloids common within the Rutaceae family and moreover are associated with quorum sensing and virulence of the human pathogen Pseudomonas aeruginosa, have been
Sven Thierbach, Max Wienhold, Susanne Fetzner, Ulrich Hennecke   +3 more
doaj   +1 more source

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

Synergistic Advanced Oxidation and Physicochemical Treatment Strategies for Antibiotic Removal and Resistance Mitigation in Water

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT The presence of antibiotics in water not only causes environmental pollution but also increases the growth of antibiotic‐resistant bacterial genes, which pose serious threats to human beings and other water residents. Large numbers of people are reportedly affected by the resistant bacterial genes, as many broad‐spectrum antibiotics are not ...
Amir Zada, Shohreh Azizi
wiley   +1 more source