Results 21 to 30 of about 11,432 (179)

Nontargeted Metabolomics Reveals the Multilevel Response to Antibiotic Perturbations

Cell Reports, 2017
Microbes have shown a remarkable ability in evading the killing actions of antimicrobial agents, such that treatment of bacterial infections represents once more an urgent global challenge.
Mattia Zampieri, Michael Zimmermann, Manfred Claassen, Uwe Sauer   +3 more
doaj   +1 more source

Quinolones-Induced Musculoskeletal, Neurological, and Psychiatric ADRs: A Pharmacovigilance Study Based on Data From the Italian Spontaneous Reporting System

Frontiers in Pharmacology, 2020
BackgroundThe use of quinolones has been associated with the development of serious and persistent adverse drug reaction (ADR) mainly affecting muscles, joints and the nervous system.
Cristina Scavone, Cristina Scavone, Annamaria Mascolo, Annamaria Mascolo, Rosanna Ruggiero, Rosanna Ruggiero, Liberata Sportiello, Liberata Sportiello, Concetta Rafaniello, Concetta Rafaniello, Liberato Berrino, Annalisa Capuano, Annalisa Capuano   +12 more
doaj   +1 more source

Assessment of the genotoxicity of quinolone and fluoroquinolones contaminated soil with the Vicia faba micronucleus test [PDF]

, 2012
The genotoxicity of quinolone and fluroquinolones was assessed using the micronucleus (MN) test on Viciafaba roots by direct contact exposure to a solid matrix.
Khadra, Ahmed, A. Khadra, Hamdi, Hassan, Hafidi, Mohamed, Bousquet‐mélou, Alain, Pinelli, Eric, Merlina, Georges, Guiresse, Agnès Maritchù, HATIFI, Mohamed, H. Hamdi, M. Guiresse, Lacroix, Marlene Z., G. Merlina, HAMDI, H, M. Hafidi, E. Pinelli, Bousquet-Mélou, Alain, Lacroix, Marlène, M.Z. Lacroix, Guiresse, Maritxu, A. Bousquet-Melou   +20 more
core   +1 more source

Rapid Phenotypic Convergence towards Collateral Sensitivity in Clinical Isolates of Pseudomonas aeruginosa Presenting Different Genomic Backgrounds

Microbiology Spectrum, 2023
Collateral sensitivity (CS) is an evolutionary trade-off by which acquisition of resistance to an antibiotic leads to increased susceptibility to another.
Sara Hernando-Amado, Carla López-Causapé, Pablo Laborda, Fernando Sanz-García, Antonio Oliver, José Luis Martínez   +5 more
doaj   +1 more source

Legionella: macrolides or quinolones? [PDF]

, 2006
Following the first outbreaks of legionnaire's disease, erythromycin emerged as the treatment of choice without the foundation of rigorous clinical trials.
Pedro-Botet, L., Yu, V.L.
core   +1 more source

Anticancer Activity of Some Ruthenium(III) Complexes with Quinolone Antibiotics: In Vitro Cytotoxicity, Cell Cycle Modulation, and Apoptosis-Inducing Properties in LoVo Colon Cancer Cell Line

Applied Sciences, 2021
Cisplatin is one of the most effective anticancer agents used to treat colon cancer, which is the third malignancy between the most common human cancers in the world, but the resistance developed represents an obstacle against the full success of ...
Mirela Mihaila, Camelia Mia Hotnog, Marinela Bostan, Alexandra Cristina Munteanu, Ileana Adela Vacaroiu, Lorelei Irina Brasoveanu, Valentina Uivarosi   +6 more
doaj   +1 more source

The Difficult Case of Crystallization and Structure Solution for the ParC55 Breakage-Reunion Domain of Topoisomerase IV from Streptococcus pneumoniae. [PDF]

, 2008
BACKGROUND: Streptococcus pneumoniae is the major cause of community-acquired pneumonia and is also associated with bronchitis, meningitis, otitis and sinusitis.
Laponogov, I, Pan, Xiao-Su, L Mark Fisher, Veselkov, DA, Sanderson, MR, Xiao-Su Pan, Sohi, MK, Mark R Sanderson, Fisher, L. Mark, Sanderson, Mark R., Laponogov, Ivan, Fisher, LM, Dennis A Veselkov, Pan, XS, Maninder K Sohi, Veselkov, Dennis A., Ivan Laponogov, Sohi, Maninder K.   +17 more
core   +1 more source

Electroreductive Intermolecular Coupling of 4‑Quinolones with Benzophenones: Synthesis of 2‑Substituted 4‑Quinolones

, 2019
The electroreductive coupling of 1-alkoxycarbonyl-4-quinolones with benzophenones in the presence of trimethylsilyl chloride gave adducts reacted at the 2-position of 4-quinolones as trimethylsilyl ethers.
Tatsuhiro Manto (7871471), Toshihiko Sakurai (1626820), Yoshie Yoshimura (7871468), Naoki Kise (1626817)   +3 more
core   +2 more sources

Divergent Synthesis of Polymethoxylated 4‑Aryl-2-quinolones

, 2016
Polymethoxylated 4-aryl-2-quinolones were synthesized from the corresponding (o-amino­phenyl)­propiolates via Cu-catalyzed hydroarylation and subsequent deprotection/lactam formation.
Tsukasa Murayama (1695832), Masatoshi Shibuya (1368624), Yoshihiko Yamamoto (1368621)   +2 more
core   +1 more source

Clerocidin interacts with the cleavage complex of Streptococcus pneumoniae topoisomerase IV to induce selective irreversible DNA damage [PDF]

, 2006
Clerocidin (CL), a diterpenoid natural product, alkylates DNA through its epoxide moiety and exhibits both anticancer and antibacterial activities. We have examined CLaction in the presence of topoisomerase IV from Streptococcus pneumoniae.
Fisher, LM, RICHTER, SARA, Giaretta, G, LEO, ELISABETTA, GIARETTA, GIULIA, Palumbo, M, Leo, E, FISHER L. M, Richter, SN, Gatto, B, GATTO, BARBARA, PALUMBO, MANLIO   +11 more
core   +1 more source