Results 11 to 20 of about 11,432 (179)

quinolones

, 2022
Archive of quinolones containing sub-folders named after each compound and its net charge. Every compound's folder contains a total of 20 files distributed into three sub-directories reporting QM (QM/), FF (FF/), and MD (MD ...
Giuliano Malloci (2060875), Silvia Gervasoni (6169202), Andrea Bosin (6743129), Helen I. Zgurskaya (3093648), Attilio Vittorio Vargiu (2358538), Paolo Ruggerone (247673)   +5 more
core   +1 more source

The evaluation of ADME and pharmacokinetic properties of decoquinate derivatives for the treatment of malaria

Frontiers in Pharmacology, 2022
The emergence of Plasmodium falciparum (Pf) parasite strains tolerant of the artemisinin component and resistant to the other drug component in artemisinin combination therapies (ACTs) used for treatment now markedly complicates malaria control.
Daniel J. Watson, Lizahn Laing, Richard M. Beteck, Liezl Gibhard, Richard K. Haynes, Lubbe Wiesner   +5 more
doaj   +1 more source

Regioselective formation of new 3-S-alkylated-1,2,4-triazole-quinolones

, 2021
Regioselective synthesis of quinolone-1,2,4-triazoles was established starting from 4-hydroxyquinol-2-ones. The strategy started by the reaction of ethyl bromoacetate with 4-hydroxyquinoline to give the corresponding ethyl oxoquinolinyl acetates, which ...
Alan B. Brown (11775964), Yaseen A.M.M. Elshaier (11775961), Martin Nieger (1628914), Mohamed Ramadan (3633547), Hazem M. Fathy (11775967), Ashraf A. Aly (3184356), Stefan Bräse (2454700), Mohamed Abd El-Aziz (11775958)   +7 more
core   +1 more source

Matrix effects and compensation measures of quinolones detection in animal derived food by HPLC-MS/MS

Zhongguo shipin weisheng zazhi, 2022
ObjectiveTo study the matrix effects （MEs） and the compensation measures of 15 quinolones （QNs） determination in animal derived food by high performance liquid chromatography-tandem mass spectrometry （HPLC-MS/MS） .MethodsFish， pork and chicken as typical
LI Daoxia, HUAGN Lijuan, GU Hui, JIANG Yanshu, YU Xiaoqin, LI Shucai   +5 more
doaj   +1 more source

Synthesis and “In Silico” Evaluation of the Biological Activity of the New Dual Inhibitors of Gyrase DNA and Topoisomerase IV

Proceedings, 2020
Quinolones are effective against a broad range of bacterial species and provide potent treatmentoptions for a few infections [1,2]. [...] 
Lucia Pintilie, Constantin Tanase, Maria Maganu, Miron Teodor Caproiu   +3 more
doaj   +1 more source

Increasing Antimicrobial Resistance and Narrowing Therapeutics in Typhoidal Salmonellae [PDF]

Journal of Clinical and Diagnostic Research, 2013
Multidrug-resistant typhoid fever (MDRTF) is a major public health problem in developing countries and is an emerging problem in the developed world.
Jaspal Kaur
doaj   +1 more source

Interaction of divalent cations, quinolones and bacteria

, 1994
The interaction between divalent cations and quinolones and the mechanism by which the former antagonizes the antimicrobial activities of the latter were investigated. In the presence of either magnesium or calcium chloride, the MICs of 18 quinolones for
Marshall, A J, Piddock, L J
core   +6 more sources

Article Review: Staphylococcus Aurous Virulence Factors and it´s Resistance to Antibiotics [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2021
Staphylococcus aureus is naturally colonizing the skin and the naris of healthy people and Staphylococcus aureus exhibits different surface factors of the cell, which play a role in their virulence.
Wafaa radef, Farkad Musa
doaj   +1 more source

Repeated Exposure of Escherichia coli to High Ciprofloxacin Concentrations Selects gyrB Mutants That Show Fluoroquinolone-Specific Hyperpersistence

Frontiers in Microbiology, 2022
Recent studies have shown that not only resistance, but also tolerance/persistence levels can evolve rapidly in bacteria exposed to repeated antibiotic treatments.
Aurore Perault, Catherine Turlan, Nathalie Eynard, Quentin Vallé, Alain Bousquet-Mélou, Etienne Giraud   +5 more
doaj   +1 more source

Effect of subinhibitory concentrations of ciprofloxacin on Mycobacterium fortuitum mutation rates [PDF]

, 2005
Objectives: Fluoroquinolones have found a place in the management of mycobacterial diseases including tuberculosis. It has been previously shown that subinhibitory concentrations of quinolones increase the mutation rate in Escherichia coli and ...
Basu, Shreya, O'Sullivan, D M, McHugh, TD, O'Sullivan, Denise M, Gillespie, S H, Dickens, A L, McHugh, T D, O'Sullivan, DM, Basu, S, Gillespie, Stephen H, Gillespie, SH, Dickens, AL, Dickens, Anne L, McHugh, Timothy D   +13 more
core   +1 more source