Hydrogen Bond Assisted Three-Component Tandem Reactions to Access N-Alkyl-4-Quinolones [PDF]
Molecules, 2023 Hydrogen-bonding catalytic reactions have gained great interest. Herein, a hydrogen-bond-assisted three-component tandem reaction for the efficient synthesis of N-alkyl-4-quinolones is described.
Huanhuan Liu +8 more
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Synthetic approach to 2-alkyl-4-quinolones and 2-alkyl-4-quinolone-3-carboxamides based on common β-keto amide precursors [PDF]
Beilstein Journal of Organic Chemistry, 2023 β-Keto amides were used as convenient precursors to both 2-alkyl-4-quinolones and 2-alkyl-4-quinolone-3-carboxamides. The utility of this approach is demonstrated with the synthesis of fourteen novel and four known quinolone derivatives, including ...
Yordanka Mollova-Sapundzhieva +3 more
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Bacterial Alkyl-4-quinolones: Discovery, Structural Diversity and Biological Properties [PDF]
Molecules, 2020 The alkyl-4-quinolones (AQs) are a class of metabolites produced primarily by members of the Pseudomonas and Burkholderia genera, consisting of a 4-quinolone core substituted by a range of pendant groups, most commonly at the C-2 position. The history of
Muhammad Saalim +2 more
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Unravelling the Genome-Wide Contributions of Specific 2-Alkyl-4-Quinolones and PqsE to Quorum Sensing in Pseudomonas aeruginosa. [PDF]
PLoS Pathog, 2016 The pqs quorum sensing (QS) system is crucial for Pseudomonas aeruginosa virulence both in vitro and in animal models of infection and is considered an ideal target for the development of anti-virulence agents.
Rampioni G +9 more
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Effective Synthesis of 4-Quinolones by Reductive Cyclization of 2′-Nitrochalcones Using Formic Acid as a CO Surrogate [PDF]
Molecules, 2023 4-Quinolones are the structural elements of many pharmaceutically active compounds. Although several approaches are known for their synthesis, the introduction of an aryl ring in position 2 is problematic with most of them. The reductive cyclization of o-
Francesco Ferretti +3 more
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Hypervalent Iodine(III)-Promoted C3–H Regioselective Halogenation of 4‑Quinolones under Mild Conditions [PDF]
ACS Omega, 2021 Fang Yang +4 more
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Electroreductive Intermolecular Coupling of 4‑Quinolones with Benzophenones: Synthesis of 2‑Substituted 4‑Quinolones [PDF]
ACS Omega, 2019 Naoki Kise +3 more
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Evaluation of the Activity of 4‑Quinolones against Multi-Life Stages of Plasmodium spp. [PDF]
ACS OmegaYasmin Annunciato +31 more
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Essential Guide of Analysis Methods Applied to Silver Complexes with Antibacterial Quinolones [PDF]
Advanced Pharmaceutical Bulletin, 2018 To describe the chemical structure and characterize physico-chemical properties of organometallic complexes it is necessary to use a complex set of analysis methods. Thus, this review has been compiled as a relevant guide which includes the most commonly
Aura Rusu, Gabriel Hancu, Silvia Imre
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Pharmaceuticals, 2022 Quinolones are one of the most extensively used therapeutic families of antibiotics. However, the increase in antibiotic-resistant bacteria has rendered many of the available compounds useless.
Beatriz Suay-García +5 more
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