Results 21 to 30 of about 95,737 (296)

Exploring the Anticancer Effects of Brominated Plastoquinone Analogs with Promising Cytotoxic Activity in MCF-7 Breast Cancer Cells via Cell Cycle Arrest and Oxidative Stress Induction

Pharmaceuticals, 2022
Plastoquinone analogs are privileged structures among the known antiproliferative natural product-based compound families. Exploiting one of these analogs as a lead structure, we report the investigation of the brominated PQ analogs (BrPQ) in ...
Ayse Tarbin Jannuzzi, Ayse Mine Yilmaz Goler, Nilüfer Bayrak, Mahmut Yıldız, Hatice Yıldırım, Betul Karademir Yilmaz, Deepak Shilkar, Raghusrinivasan Jayaprakash Venkatesan, Venkatesan Jayaprakash, Amaç Fatih TuYuN   +9 more
doaj   +1 more source

NQO2 is a reactive oxygen species generating off-target for acetaminophen [PDF]

, 2014
The analgesic and antipyretic compound acetaminophen (paracetamol) is one of the most used drugs worldwide. Acetaminophen overdose is also the most common cause for acute liver toxicity.
Teemu P. Miettinen, Mikael Björklund, Miettinen, Teemu P., Björklund, Mikael   +3 more
core   +1 more source

Syntheses and Absolute Stereochemistries of UPA0043 and UPA0044, Cytotoxic Antibiotics Having a p-Quinone-methide Structure

, 2016
The first syntheses of new antibiotics UPA0043 and UPA0044 were accomplished starting from commercially available 18β-glycyrrhetinic acid and vanillin.
Akira Kawashima (362269), Ken-ichi Takao (1453246), Tomohito Kozaki (3064743), Tomoko Sasaki (3064746), Kin-ichi Tadano (1453249), Yumiko Yanagisawa (3064752), Hideki Shinonaga (3064749)   +6 more
core   +2 more sources

Menadione: a platform and a target to valuable compounds synthesis

Beilstein Journal of Organic Chemistry, 2022
Naphthoquinones are important natural or synthetic compounds belonging to the general class of quinones. Many compounds in this class have become drugs that are on the pharmaceutical market for the treatment of various diseases.
Acácio S. de Souza, Ruan Carlos B. Ribeiro, Dora C. S. Costa, Fernanda P. Pauli, David R. Pinho, Matheus G. de Moraes, Fernando de C. da Silva, Luana da S. M. Forezi, Vitor F. Ferreira   +8 more
doaj   +1 more source

The Synthesis of Diquinone and Dihydroquinone Derivatives of Calix[4]arene and Electrochemical Characterization on Au(111) surface.

Acta Chimica Slovenica, 2016
Several new electroactive diquinone and dihydroquinone derivatives of calix[4]arene bearing anchor functional groups were designed, synthesized and characterized. A method for selective protection of the hydroquinone –OH groups with trimethylsilyl groups
Bostjan Genorio
doaj   +1 more source

The Candida albicans ζ-crystallin homolog Zta1 promotes resistance to oxidative stress

mSphere, 2023
The fungal pathogen Candida albicans is capable of causing lethal infections in humans. Its pathogenic potential is due in part to the ability to resist various stress conditions in the host, including oxidative stress.
Rafael M. Gandra, Chad J. Johnson, Jeniel E. Nett, James B. Konopka   +3 more
doaj   +1 more source

A copper-induced quinone degradation pathway provides protection against combined copper/quinone stress in Lactococcus lactis IL1403. [PDF]

, 2015
Quinones are ubiquitous in the environment. They occur naturally but are also in widespread use in human and industrial activities. Quinones alone are relatively benign to bacteria, but in combination with copper, they become toxic by a mechanism that ...
Abicht, Helge, Abicht, Helge K., Mancini, Stefano, Solioz, Marc, Gonskikh, Yulia D., Gonskikh, Yulia, Mancini S, Gonskikh Y, Abicht HK, Solioz M   +9 more
core   +1 more source

Environmentally Friendly Expeditious One-Pot Electrochemical Synthesis of Bis-Catechol-Thioether Metabolites of Ecstasy: in vitro Neurotoxic Effects in the Rat Hippocampus

International Journal of Electrochemical Science, 2008
A straightforward one-pot electrochemical synthesis of bis-catechol-thioether metabolites of MDMA (ecstasy), 2,5-bis(glutathion-S-yl)-N-methyl-α-methyldopamine and 2,5-bis(N-acetylcystein-S-yl)-N-methyl-α-methyldopamine, in acceptable yields and high ...
Anne Felim, Anne Neudörffer, François P. Monnet, Martine Largeron   +3 more
doaj   +1 more source

Comparison of calculated and experimental isotope edited FTIR difference spectra for purple bacterial photosynthetic reaction centers with different quinones incorporated into the QA binding site.

Frontiers in Plant Science, 2013
Previously we have shown that ONIOM type (QM/MM) calculations can be used to simulate isotope edited FTIR difference spectra for neutral ubiquinone in the QA binding site in Rhodobacter sphaeroides photosynthetic reaction centers.
Nan eZhao, Hari P Lamichanne, Gary eHastings   +2 more
doaj   +1 more source

A novel quinone: Quinone methide isomerase generates quinone methides in insect cuticle

FEBS Letters, 1988
Insoluble cuticle‐bound enzyme(s) of Manduca sexta pharate pupae, which is known to convert N‐acetyldopamine to N‐acetylnorepinephrine through the intermediate formation of quinone methide, also converted exogenously supplied N‐acetyldopamine quinone to N‐acetylnorepinephrine.
Saul, Steven, Sugumaran, Manickam
openaire   +2 more sources