Results 41 to 50 of about 35,652 (256)

Anticancer Effect and Structure-Activity Analysis of Marine Products Isolated from Metabolites of Mangrove Fungi in the South China Sea

Marine Drugs, 2010
Marine-derived fungi provide plenty of structurally unique and biologically active secondary metabolites. We screened 87 marine products from mangrove fungi in the South China Sea for anticancer activity by MTT assay.
Li-yang Tao, Jian-ye Zhang, Yong-ju Liang, Li-ming Chen, Li-sheng Zheng, Fang Wang, Yan-jun Mi, Zhi-gang She, Kenneth Kin Wah To, Yong-cheng Lin, Li-wu Fu   +10 more
doaj   +1 more source

A Chemical Framework for Engineering Extracellular Vesicles’ Biointerface to Advance Precision Therapeutics

Advanced Materials, EarlyView.
Extracellular vesicles (EVs) are cell‐derived nanoparticles that mediate intercellular communication through their dynamic biointerfaces. Owing to their intrinsic biological functions, EVs have emerged as promising platforms for biomedical applications.
Leila Pourtalebi Jahromi, Felix Geng, Jan‐Noël Frenzke, Gregor Fuhrmann   +3 more
wiley   +1 more source

Investigation into the role of carboxylic acid and phenolic hydroxyl groups in the plant biostimulant activity of a humic acid purified from an oxidized sub-bituminous coal

Frontiers in Plant Science
IntroductionHumic substances (HS) are increasingly being applied as crop plant biostimulants because they have been shown to increase plant productivity, especially under environmentally stressful conditions.
Richard T. Lamar, Jason Gralian, William C. Hockaday, Maria Jerzykiewicz, Hiarhi Monda   +4 more
doaj   +1 more source

Quinone and Hydroquinone Metabolites from the Ascidians of the Genus Aplidium

Marine Drugs, 2014
Ascidians of the genus Aplidium are recognized as an important source of chemical diversity and bioactive natural products. Among the compounds produced by this genus are non-nitrogenous metabolites, mainly prenylated quinones and hydroquinones.
Camila Spereta Bertanha, Ana Helena Januário, Tavane Aparecida Alvarenga, Letícia Pereira Pimenta, Márcio Luis Andrade e Silva, Wilson Roberto Cunha, Patrícia Mendonça Pauletti   +6 more
doaj   +1 more source

Features of idebenone and related short-chain quinones that rescue ATP levels under conditions of impaired mitochondrial complex I. [PDF]

PLoS ONE, 2012
Short-chain quinones have been investigated as therapeutic molecules due to their ability to modulate cellular redox reactions, mitochondrial electron transfer and oxidative stress, which are pathologically altered in many mitochondrial and neuromuscular
Michael Erb, Barbara Hoffmann-Enger, Holger Deppe, Michael Soeberdt, Roman H Haefeli, Christian Rummey, Achim Feurer, Nuri Gueven   +7 more
doaj   +1 more source

Quinone and non-quinone redox couples in Complex III [PDF]

Journal of Bioenergetics and Biomembranes, 2008
The Q cycle mechanism proposed by Peter Mitchell in the 1970's explicitly considered the modification of ubiquinone two-electron redox properties upon binding to Complex III to match the thermodynamics of the other single-electron redox cofactors in the complex, and guide electron transfer to support the generation of a proton electro-chemical gradient
Zhang, Haibo, Chobot, Sarah E., Osyczka, Artur, Wraight, Colin A., Dutton, P. Leslie, Moser, Christopher C.   +5 more
openaire   +3 more sources

Defect‐Engineered Microwave‐Responsive Ni@C Composites From Waste PET for Catalytic Plastic Upcycling

Advanced Materials, EarlyView.
A circular upcycling strategy transforms waste poly(ethylene terephthalate) bottles into microwave‐responsive Ni@C catalyst featuring lattice‐distorted nickel cores and defective carbon shells. These strain‐rich heterointerfaces enhance dielectric loss and promote localized microwave hotspots, accelerating peroxymonosulfate activation and polymer‐chain
Xiao Lu, Shiying Ren, Jingkai Lin, Kunsheng Hu, Yalan Mo, Shaobin Wang, Wenjie Tian, Xiaoguang Duan   +7 more
wiley   +1 more source

Research Progress on Chemical Compositions, Pharmacological Activities, and Toxicities of Quinone Compounds in Traditional Chinese Medicines

Toxics
With the continuous development of research on natural medicines, quinone compounds have become increasingly important in the research field of chemical constituents of natural treatments.
Zhe Li, Rui Yao, Hong Guo, Wenguang Jing, Xiaohan Guo, Xiaoqiu Liu, Yingni Pan, Pei Cao, Lei Zhang, Jianbo Yang, Xianlong Cheng, Feng Wei   +11 more
doaj   +1 more source

Quinones from Cordia species from 1972 to 2023: isolation, structural diversity and pharmacological activities

Natural Products and Bioprospecting, 2023
Plants of the genus Cordia (Boraginaceae family) are widely distributed in the tropical regions of America, Africa, and Asia. They are extensively used in folk medicine due to their rich medicinal properties. This review presents a comprehensive analysis
Rostanie Dongmo Zeukang, Jarmo-Charles Kalinski, Babalwa Tembeni, Eleonora D. Goosen, Jacqueline Tembu, Turibio Tabopda Kuiate, Dominique Serge Ngono Bikobo, Maurice Tagatsing Fotsing, Alex de Théodore Atchadé, Xavier Siwe-Noundou   +9 more
doaj   +1 more source

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source