Results 51 to 60 of about 710 (185)

Identification of a Functional CYP2C8 Variant Allele that Alters Splicing, Reduces Protein Expression, and Increases Drug Exposure

Clinical Pharmacology &Therapeutics, EarlyView.
This study investigated genetic determinants of the pharmacokinetics of the CYP2C8 index drugs repaglinide and gemfibrozil, and their interaction in healthy participants. Sequencing data from a study with montelukast revealed a novel functional CYP2C8 allele (rs2071426, CYP2C8*19), predicted to create an intronic splice donor site.
Anssi J. H. Mykkänen, Päivi Hirvensalo, Kathrin Klein, Dorota Kaminska, Markus Grube, Tuija Tapaninen, Johanna I. Kiiski, Mikko Neuvonen, Ville T. Männistö, Jussi Pihlajamäki, Mladen Tzvetkov, Matthias Schwab, Aleksi Tornio, Janne T. Backman, Mikko Niemi   +14 more
wiley   +1 more source

Barriers to using of Quintuple Helix model to create innovations in Polish regions

Scientific Papers of Silesian University of Technology. Organization and Management Series, 2020
Purpose: The main purpose of the paper is to present and discuss the assumptions of the model and indicate whether the regional innovativeness can be improved with the help of multi-branch co-operation oriented so as to form new solutions to contemporary development problems.
openaire   +1 more source

How Institutional Environments Shape the ESG–Growth Relation: Evidence From Europe

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT As global financial markets increasingly integrate non‐financial criteria, companies are reinforcing the strategic role of sustainability and its impact on market value, although this cannot overlook how different institutional structures shape investor perceptions.
Laura Bango‐López, Cristina Gutiérrez‐López, Paula Castro, María Belén Lozano‐García   +3 more
wiley   +1 more source

The Sextuple Helix Innovation Model: Positioning Generative AI as an Epistemic Agent in Creative and Sustainable Knowledge Economies

Social Sciences
This paper introduces the Sextuple Helix Innovation Model as an extension of the Quintuple Helix Innovation Model by Carayannis and Campbell. The epistemic perspective considers the understanding of generative AI (GenAI) as a sixth helix of knowledge ...
Lutz Peschke
doaj   +1 more source

A New High‐Pressure Polymorph of MgTe2O5 with a Unique Crystal Structure

European Journal of Inorganic Chemistry, EarlyView.
MgTe2O5 synthesized under special high‐pressure/high‐temperature conditions of 8 GPa and 800 °C exhibits a unique crystal structure consisting of fused sechser rings built from pseudooctahedral [TeO5]6– and trigonal‐pyramidal [TeO3]2– units. The single‐crystal structure and temperature‐dependent powder diffraction data are presented.
Benjamin J. Pullicino, Gunter Heymann
wiley   +1 more source

Fostering Work Readiness in Gen Z through Quintuple Helix, 4P's Creativity

Jurnal Aplikasi Manajemen
This study aims to explore gender differences in creativity exploration and work readiness among Generation Z employees in the workplace. It integrates the Quintuple Helix model with the 4P's creativity model to comprehensively understand how gender ...
Ilzar Daud, Melia Wida Rahmayani, Syahrul Nugraha, Wayan Suryathi, Danny Hidayat   +4 more
doaj   +1 more source

Linking Loops: How Digital Platforms Orchestrate Circular Economy Networks

Sustainable Development, EarlyView.
ABSTRACT This study investigates how digital platforms can drive the transition to a circular economy by developing multi‐stakeholder collaboration and fostering innovation. Using the Italian Circular Economy Stakeholder Platform (ICESP) as case study, it explores the mechanisms through which digital infrastructures orchestrate knowledge flows ...
Anna Prisco, Andrea Rey, Mauro Sciarelli, Danilo Tuccillo   +3 more
wiley   +1 more source

Probing the Energy Trilemma Pillars: Do Innovation Pathways Deliver Cleaner and More Equitable Energy Systems?

Sustainable Development, EarlyView.
ABSTRACT Balancing reliable energy supply, equitable access, and environmental sustainability is a central challenge of the global energy transition. This study examines how innovation influences the energy trilemma by shaping energy security, energy equity, and environmental sustainability across 115 countries from 2011 to 2023.
Kingsley Imandojemu, Omozele Lynda Showunmi, Felix Orole, Damilola Felix Eluyela, Hammed Oluwaseyi Musibau, Romanus Osabohien   +5 more
wiley   +1 more source

The Quintuple Helix Modeling Technological Innovation: Characterization and the Status of Business Accelerators in a Metropolitan Region

, 2021
Lara, J. E., Esteves, C. M. A., Cremonez, V. G., & Ribeiro, R. M. (2021). The Quintuple Helix Modeling Technological Innovation: Characterization and the Status of Business Accelerators in a Metropolitan Region. International Journal of Professional Business Review, 6(1), e0221.
José Edson Lara, Claudia Maria Araújo Esteves, Victor Gonçalves Cremonez, Rodrigo Medeiros Ribeiro   +3 more
openaire   +1 more source

Institutional Determinants of Environmental Disclosure for Sustainable Development: The Moderating Role of Gender‐Diverse Boards

Sustainable Development, EarlyView.
ABSTRACT This study examines the institutional determinants of environmental disclosure in the context of sustainable development and analyses the moderating role of board gender diversity in this relationship. Using an international sample of 26 countries over the period 2014–2023, we explore how macro‐level socioeconomic, cultural, political, and ...
Carmelo Reverte, María Consuelo Pucheta‐Martínez, Isabel Gallego‐Álvarez   +2 more
wiley   +1 more source