Results 51 to 60 of about 706 (185)

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

Die Quintuple-Helix als Modell für Wissenstransfer auf Augenhöhe.

, 2022
Die Quintuple-Helix als Modell für Wissenstransfer auf Augenhöhe: weiter bilden 3 ...
Inka Engel, Miriam Voigt
openaire   +1 more source

Topological Materials and Related Applications

Advanced Electronic Materials, EarlyView.
This review covers topological materials—including topological insulators, quantum valley Hall and quantum spin Hall insulators, and topological Weyl and Dirac semimetals—as well as their most recent advancements in fields such as spintronics, electronics, photonics, thermoelectrics, and catalysis.
Carlo Grazianetti, Roberto Mantovan, Emanuele Longo, Harold J. W. Zandvliet, Pantelis Bampoulis, Yu Pan, Fan Li, Xia Wang, Payton Downey, Alessandro Molle   +9 more
wiley   +1 more source

Civic university model as living lab : potential and challenges

Multidisciplinary Adaptive Climate Insights
To construct a dynamic model inside the university that emphasizes its position within society and expedites sustainable development goals, this article discusses the civic university and how it can benefit from emerging concepts like the Living Lab and ...
Rania Rageh
doaj   +1 more source

AS‐pHopt: An Optimal pH Prediction Model Enhanced by Active Site of Enzymes

Advanced Intelligent Discovery, EarlyView.
To address the low accuracy of enzyme optimal pH (pHopt) prediction, this study develops active site‐based pHopt (AS‐pHopt), a prediction model enhanced by active site information and pseudo‐label prediction. Integrating key structural and physicochemical features affecting enzyme pHopt, AS‐pHopt uses Evolutionary Scale Modeling (ESM)‐2 with active ...
Wenxiang Song, Xinmin Li, Hongbo Yu, Le Xiong, Guixia Liu, Weihua Li, Yun Tang   +6 more
wiley   +1 more source

The Sextuple Helix Innovation Model: Positioning Generative AI as an Epistemic Agent in Creative and Sustainable Knowledge Economies

Social Sciences
This paper introduces the Sextuple Helix Innovation Model as an extension of the Quintuple Helix Innovation Model by Carayannis and Campbell. The epistemic perspective considers the understanding of generative AI (GenAI) as a sixth helix of knowledge ...
Lutz Peschke
doaj   +1 more source

A Chiral Saddle‐Shaped Nanographene With Two Heptagon‐Embedded [4]Helicenes

Angewandte Chemie International Edition, EarlyView.
We present a novel synthetic strategy toward a chiral saddle‐shaped nanographene (cSNG) via a two‐step oxidation of a prochiral anthracene precursor. The Scholl‐type oxidation first yields a key intermediate with sp3‐defect heptagons, and subsequent oxidative dehydrogenation affords fully conjugated cSNG.
Felix Trautner, Boris Borrisov, Philipp Royla, Hongqing Zhao, Hartmut Komber, Li Wan, Evgenia Dmitrieva, Ji Ma, Jan J. Weigand, Qun Yang, Xinliang Feng, Wenhui Niu   +11 more
wiley   +1 more source

Fostering Work Readiness in Gen Z through Quintuple Helix, 4P's Creativity

Jurnal Aplikasi Manajemen
This study aims to explore gender differences in creativity exploration and work readiness among Generation Z employees in the workplace. It integrates the Quintuple Helix model with the 4P's creativity model to comprehensively understand how gender ...
Ilzar Daud, Melia Wida Rahmayani, Syahrul Nugraha, Wayan Suryathi, Danny Hidayat   +4 more
doaj   +1 more source

Highly Potent Fluorogenic Ligands for Triplex DNA: 5‐Substituted 2‐(Naphthalen‐2‐yl)‐4H‐Chromen‐4‐Ones

Chemistry – A European Journal, EarlyView.
5‐Substituted 2‐(naphthalen‐2‐yl)‐4H‐chromen‐4‐ones are reported as a novel class of highly potent and selective triplex DNA ligands. These ligands induce triplex formation at submicromolar concentrations and inhibit enzymatic activity via ligand‐mediated triplex formation.
Nghia Tran, Landy Gu, Krege M. Christison, Kalee Thao, Liang Xue   +4 more
wiley   +1 more source

Barriers to using of Quintuple Helix model to create innovations in Polish regions

Scientific Papers of Silesian University of Technology. Organization and Management Series, 2020
Purpose: The main purpose of the paper is to present and discuss the assumptions of the model and indicate whether the regional innovativeness can be improved with the help of multi-branch co-operation oriented so as to form new solutions to contemporary development problems.
openaire   +1 more source