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Towards quorum-quenching catalytic antibodies
Chem. Commun., 2009The development of a novel method to attenuate bacterial virulence is reported, which is based upon the use of designed transition-state analogues to select human catalytic antibodies capable of degrading bacterial quorum-sensing molecules.
Prashant B, Kapadnis +5 more
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Journal of Biotechnology, 2015
Bacteria use cell-to-cell communication systems based on chemical signal molecules to coordinate their behavior within the population. These quorum sensing systems are potential targets for antivirulence therapies, because many bacterial pathogens control the expression of virulence factors via quorum sensing networks.
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Bacteria use cell-to-cell communication systems based on chemical signal molecules to coordinate their behavior within the population. These quorum sensing systems are potential targets for antivirulence therapies, because many bacterial pathogens control the expression of virulence factors via quorum sensing networks.
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Generation of Quorum Quenching Antibodies
2010The exchange of information within and among bacterial populations using small diffusible molecules has been termed "quorum sensing" (QS). Due to the extracellular distribution of the QS autoinducer molecules and the evolutionary highly conserved nature of signaling components, microbial QS systems represent an excellent target for anti-infective ...
Gunnar F, Kaufmann +4 more
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Current Opinion in Pharmacology, 2013
With the emergence of microbial pathogens increasingly resistant against commonly used antibiotics, new treatment strategies are desperately needed. Bacterial quorum sensing has attracted a lot of attention over the last decade as a potential new target for antimicrobial therapy.
Jie, Zhu, Gunnar F, Kaufmann
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With the emergence of microbial pathogens increasingly resistant against commonly used antibiotics, new treatment strategies are desperately needed. Bacterial quorum sensing has attracted a lot of attention over the last decade as a potential new target for antimicrobial therapy.
Jie, Zhu, Gunnar F, Kaufmann
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Quorum quenching and proactive host defense
Trends in Plant Science, 2003Both plants and humans have inducible defense mechanisms. This passive defense strategy leaves the host unprotected for a period of time until resistance is activated. Moreover, many bacterial pathogens have evolved cell-cell communication (quorum-sensing) mechanisms to mount population-density-dependent attacks to overwhelm the host's defense ...
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Quorum Quenching Applications in Plant Biotechnology
2023Quorum sensing is a signal transmission and recognition system used by bacterial cells for several biochemical and physiological functions, including pathogenicity, and is significant in resisting the plant immune system. While the molecules and the chemical reactions involved vary among different classes of bacteria, the system involves a molecule ...
D. Rathnaprabha +2 more
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Biofouling Control by Quorum Quenching
2015Bacteria above a threshold cell density regulate the expression of a specific group of their genes in response to small signal molecules called autoinducers. This twitter communication phenomenon is called quorum sensing (QS). Among the various genetic expressions mediated by QS , biofilm formation and expression of virulence factors are the most ...
Vipin C. Kalia +3 more
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Quorum Quenching: Impact and Mechanisms
2014This chapter focuses on the impact and molecular mechanisms of quorum quenching, with emphasis on quorum-quenching enzymes and other signal disruption mechanisms. There are five key processes in quorum-sensing circuit, (i) signal generation, (ii) signal transportation, (iii) signal accumulation, (iv) signal recognition, and (v) signal autoinduction ...
Lian-Hui Wang +2 more
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Quorum Quenching in Anti-virulence Therapy
2023The quest for new anti-virulence medications has been sparked by the rising antibiotic resistance rates of pathogenic bacteria. By interfering with vital components of bacteria, such as their cell walls, nucleic acids and protein biosynthesis, conventional antibiotics kill or restrict bacterial growth.
Katherine Georgina Menon +3 more
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Journal of Chemical Technology & Biotechnology, 2018
AbstractBACKGROUNDQuorum sensing (QS) could regulate gene expression so as to mediate some bacterial behaviors such as the production of extracellular polymeric substances (EPS) and biofilm formation. In this study, a quorum quenching (QQ) bacterium was isolated from an indigenous lab‐scale membrane bioreactor (MBR) and encapsulated in a dumpling ...
Yanling Gu +8 more
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AbstractBACKGROUNDQuorum sensing (QS) could regulate gene expression so as to mediate some bacterial behaviors such as the production of extracellular polymeric substances (EPS) and biofilm formation. In this study, a quorum quenching (QQ) bacterium was isolated from an indigenous lab‐scale membrane bioreactor (MBR) and encapsulated in a dumpling ...
Yanling Gu +8 more
openaire +1 more source