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Polyphenols and CRISPR as Quorum Quenching Agents in Antibiotic-Resistant Foodborne Human Pathogens (Salmonella Typhimurium, Campylobacter jejuni and Escherichia coli 0157:H7). [PDF]
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2021
Bakterien sind in der Lage, ihre Artgenossen in der Umgebung über unterschiedliche Signalmoleküle wahrzunehmen und über bestimmte Signalwege auf steigendes Zellwachstum gemeinschaftlich zu reagieren. Bezeichnet wird dieser Vorgang als Quorum Sensing und stellt ein Art bakterielle Sprache dar. Bei pathogenen Organismen führt diese Kommunikation meist zu
Vollstedt, Christel, Streit, Wolfgang
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Bakterien sind in der Lage, ihre Artgenossen in der Umgebung über unterschiedliche Signalmoleküle wahrzunehmen und über bestimmte Signalwege auf steigendes Zellwachstum gemeinschaftlich zu reagieren. Bezeichnet wird dieser Vorgang als Quorum Sensing und stellt ein Art bakterielle Sprache dar. Bei pathogenen Organismen führt diese Kommunikation meist zu
Vollstedt, Christel, Streit, Wolfgang
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Towards quorum-quenching catalytic antibodies
Chem. Commun., 2009The development of a novel method to attenuate bacterial virulence is reported, which is based upon the use of designed transition-state analogues to select human catalytic antibodies capable of degrading bacterial quorum-sensing molecules.
Prashant B, Kapadnis +5 more
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Current Opinion in Pharmacology, 2013
With the emergence of microbial pathogens increasingly resistant against commonly used antibiotics, new treatment strategies are desperately needed. Bacterial quorum sensing has attracted a lot of attention over the last decade as a potential new target for antimicrobial therapy.
Jie, Zhu, Gunnar F, Kaufmann
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With the emergence of microbial pathogens increasingly resistant against commonly used antibiotics, new treatment strategies are desperately needed. Bacterial quorum sensing has attracted a lot of attention over the last decade as a potential new target for antimicrobial therapy.
Jie, Zhu, Gunnar F, Kaufmann
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Quorum Quenching for Sustainable Environment
2021Quorum quenching is the process that prevents quorum sensing through the disruption of signalling cascade and bacterial communication among themselves mediated by the degradation of the signalling molecules. Therefore, quorum quenching has a considerable contribution in the negative regulation of threatening diseases and eventually increasing soil ...
Sumira Malik +6 more
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Biotechnological applications of quorum quenching enzymes
Chemico-Biological Interactions, 2017Numerous bacteria use quorum sensing (QS) to synchronize their behavior and monitor their population density. They use signaling molecules known as autoinducers (AI's) that are synthesized and secreted into their local environment to regulate QS-dependent gene expression. Among QS-regulated pathways, biofilm formation and virulence factor secretion are
Bzdrenga, Janek +6 more
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Journal of Biotechnology, 2015
Bacteria use cell-to-cell communication systems based on chemical signal molecules to coordinate their behavior within the population. These quorum sensing systems are potential targets for antivirulence therapies, because many bacterial pathogens control the expression of virulence factors via quorum sensing networks.
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Bacteria use cell-to-cell communication systems based on chemical signal molecules to coordinate their behavior within the population. These quorum sensing systems are potential targets for antivirulence therapies, because many bacterial pathogens control the expression of virulence factors via quorum sensing networks.
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2023
Antibiotic resistance is a global health concern. Strains of pathogenic microorganisms that have developed resistance to multiple antibiotics, such as MRSA, are extremely difficult to treat, and alternative methods for tackling pathogenic microorganisms are in demand.
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Antibiotic resistance is a global health concern. Strains of pathogenic microorganisms that have developed resistance to multiple antibiotics, such as MRSA, are extremely difficult to treat, and alternative methods for tackling pathogenic microorganisms are in demand.
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Generation of Quorum Quenching Antibodies
2010The exchange of information within and among bacterial populations using small diffusible molecules has been termed "quorum sensing" (QS). Due to the extracellular distribution of the QS autoinducer molecules and the evolutionary highly conserved nature of signaling components, microbial QS systems represent an excellent target for anti-infective ...
Gunnar F, Kaufmann +4 more
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Quorum quenching and proactive host defense
Trends in Plant Science, 2003Both plants and humans have inducible defense mechanisms. This passive defense strategy leaves the host unprotected for a period of time until resistance is activated. Moreover, many bacterial pathogens have evolved cell-cell communication (quorum-sensing) mechanisms to mount population-density-dependent attacks to overwhelm the host's defense ...
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