Results 61 to 70 of about 281,005 (235)

Circulating Tumor Cells Shed Shearosome Extracellular Vesicles in Capillary Bifurcations That Activate Endothelial and Immune Cells

Advanced Science, EarlyView.
Using microfluidic models of capillary networks, this study discovered that fluid shear stresses on circulating tumor cells transiting through capillary‐sized bifurcations shed a novel class of shear‐dependent large extracellular vesicle, “shearosomes”, whose proteome comprises of over 3000 distinct proteins.
Angelos Vrynas, Salime Bazban‐Shotorbani, Sara Arfan, Karishma Satia, Brian Cunningham, Gauhar Sagindykova, Mymuna Ashna, Aoyu Zhang, Diana Visan, Aisher Chen, Teige Matthews‐Palmer, Mathew Carter, Fiona Blackhall, Kathryn L. Simpson, Caroline Dive, Paul Huang, Sam H. Au   +16 more
wiley   +1 more source

Quorum-quenching microbial infections: mechanisms and implications [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2007
The discovery of antibiotics early in the past century marked the beginning of active control and prevention of infectious microbial diseases. However, extensive use of antibiotics has also unavoidably resulted in the emergence of ‘superbugs’ that resist conventional antibiotics.
Yi-Hu Dong, Lian-Hui Zhang, Lian-Hui Zhang, Lian-Hui Wang   +3 more
openaire   +3 more sources

Advancing Antibiotic-Resistant Microbe Combat: Nanocarrier-Based Systems in Combination Therapy Targeting Quorum Sensing

Pharmaceutics
The increase in antibiotic-resistant bacteria presents a significant risk to worldwide public health, emphasizing the necessity of novel approaches to address infections.
Sanchaita Rajkhowa, Safrina Zeenat Hussain, Manisha Agarwal, Alaiha Zaheen, Sami A. Al-Hussain, Magdi E. A. Zaki   +5 more
doaj   +1 more source

Design and Development of rGO and Polymer‐Based Patches for Cardiac Tissue Engineering

Journal of Applied Polymer Science, EarlyView.
ABSTRACT Myocardial infarction (MI), caused by coronary artery blockage, is a leading cause of death worldwide and results in permanent heart damage. Current treatments have limited success in fully restoring cardiac function, leading to increased interest in tissue engineering solutions.
Israa F. Abdulazez, Busra Oktay, Hilal Yilmaz, Ayse Betul Bingol, Alpay Kose, Ilkay Şenel, Eray Altan, Cem Bülent Üstündağ   +7 more
wiley   +1 more source

Evolution of Resistance to Quorum Quenching in Digital Organisms [PDF]

Artificial Life, 2012
Quorum sensing (QS) is a collective behavior whereby actions of individuals depend on the density of the surrounding population. Bacteria use QS to trigger secretion of digestive enzymes, formation and destruction of biofilms, and, in the case of pathogenic organisms, expression of virulence factors that cause disease. Investigations of mechanisms that
Christopher M. Waters, Philip K. McKinley, David B. Knoester, Brian D. Connelly, Benjamin E. Beckmann   +4 more
openaire   +2 more sources

Structural and Biochemical Characterization of AaL, a Quorum Quenching Lactonase with Unusual Kinetic Properties

Scientific Reports, 2018
Quorum quenching lactonases are enzymes that are capable of disrupting bacterial signaling based on acyl homoserine lactones (AHL) via their enzymatic degradation.
Celine Bergonzi, Michael Schwab, Tanushree Naik, David Daudé, Eric Chabrière, Mikael Elias   +5 more
doaj   +1 more source

Quorum Quenching of Nitrobacter winogradskyi Suggests that Quorum Sensing Regulates Fluxes of Nitrogen Oxide(s) during Nitrification

mBio, 2016
Quorum sensing (QS) is a widespread process in bacteria used to coordinate gene expression with cell density, diffusion dynamics, and spatial distribution through the production of diffusible chemical signals.
Brett L. Mellbye, Andrew T. Giguere, Peter J. Bottomley, Luis A. Sayavedra-Soto   +3 more
doaj   +1 more source

Design and Synthesis of Triazole‐Based p‐tert‐Butylcalix[4]Arene Conjugates and Evaluation of Their Antimicrobial, Antibiofilm, and Anti‐Quorum‐Sensing Activities

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Macrocyclic calix[n]arenes have many applications, with diverse structures that can easily be functionalized either on upper or lower rims, mostly to impart solubility and improve biological activities. In this study, triazole‐based p‐tert‐butylcalix[4]arene conjugates (AT10a and AT10b) and their p‐tert‐butylphenol analogs (AT10b and AT11b ...
Alfred Ngenge Tamfu, Selahattin Bozkurt, Ozgur Ceylan   +2 more
wiley   +1 more source

Quorum quenching of Streptococcus mutans via the nano-quercetin-based antimicrobial photodynamic therapy as a potential target for cariogenic biofilm

BMC Microbiology, 2022
Background Quorum sensing (QS) system can regulate the expression of virulence factors and biofilm formation in Streptococcus mutans . Antimicrobial photodynamic therapy (aPDT) inhibits quorum quenching (QQ), and can be used to prevent microbial biofilm.
M. Pourhajibagher, M. Alaeddini, S. Etemad-Moghadam, Bahman Rahimi Esboei, Rashin Bahrami, Rezvaneh sadat Miri Mousavi, A. Bahador   +6 more
semanticscholar   +1 more source

Synthetic Biology‐Based Engineering Living Therapeutics for Antimicrobial Application

Exploration, EarlyView.
This perspective highlights synthetic biology‐driven antibacterial strategies, focusing on three innovative approaches: engineered bacteriophages for precision bacterial targeting, reprogrammed microbes that detect quorum‐sensing signals or metabolites to release antimicrobials, and engineering mammalian cells that recognize pathogen‐associated ...
Shun Huang, Shuihao Zhao, Haijie Zhao, Mingzhang Wen, Zhong Guo   +4 more
wiley   +1 more source