Results 251 to 260 of about 13,305 (277)

Quorum sensing inhibitors: a patent review

Expert Opinion on Therapeutic Patents, 2013
Quorum sensing (QS) is a cell-to-cell communication that regulates gene expression and coordinates their behavior in accordance with the cell population density as a result of discerning molecules termed autoinducers (AIs). The processes that QS governed include biofilm formation, bacterial virulence, antibiotic production, competence, conjugation ...
Tianyu, Jiang, Minyong, Li
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Inhibition of quorum sensing-controlled biofilm formation in Pseudomonas aeruginosa by quorum-sensing inhibitors

Microbial Pathogenesis, 2017
Antimicrobial therapy against extensively drug-resistant (XDR) P. aeruginosa biofilms is less efficient compared to the treatment of equal bacterial counts of free-floating planktonic cells, which has become a serious threat in hospital environment. P.
Ellappan, Kalaiarasan, Kottha, Thirumalaswamy, Belgode Narasimha, Harish, Vasuki, Gnanasambandam, Veeresh Kumar, Sali, James, John   +5 more
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Virulence Regulation and Quorum Sensing in Staphylococcal Infections: Competitive AgrC Antagonists as Quorum Sensing Inhibitors

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Weng C, Chan, Barry J, Coyle, Paul, Williams   +2 more
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Fungal Quorum Sensing Inhibitors

2014
Adaptation to various ecosystems is important to all microbes for growth and survival. Pathogenic microbes, especially bacteria, have developed mechanisms of synchronised expression of virulence genes with increasing population density through quorum sensing, enabling their survival in various host organisms.
Rohit Sharma, Kamlesh Jangid
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Design, synthesis and evaluation of oxazolopyridinone derivatives as quorum sensing inhibitors

Bioorganic Chemistry, 2022
The antibiotic crisis is associated with the appearance of multidrug resistant (MDR) pathogens, which has caused severe bacterial infections and imposed a huge burden on modern society. Therefore, there is an urgent need to develop new antibacterial drugs with novel mechanism of action.
Weijin, Chen, Panpan, Zhang, Ting, Guo, Xiaotong, Gu, Bingfang, Bai, Shenyan, Zhang, Xiaohong, Chang, Yingmei, Wang, Shutao, Ma   +8 more
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Biofilm and Quorum Sensing inhibitors: the road so far

Expert Opinion on Therapeutic Patents, 2020
Biofilm is a complex aggregation of microorganisms characterized by the presence of a dynamic, adhesive and protective extracellular matrix composed of polysaccharides, proteins and nucleic acids. It is estimated that the vast majority of human infections are related to the biofilm in which the microorganisms reside and communicate with each other ...
Carradori S., Di Giacomo N., Lobefalo M., Luisi G., Campestre C., Sisto F.   +5 more
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Equisetin as potential quorum sensing inhibitor of Pseudomonas aeruginosa

Biotechnology Letters, 2018
To screen for the quorum-sensing (QS) inhibitors from marine-derived fungi and evaluate their anti-QS properties in Pseudomonas aeruginosa.QS inhibitory activity was found in secondary metabolites of a marine fungus Fusarium sp. Z10 using P. aeruginosa QSIS-lasI biosensor.
Mengmeng, Zhang, Mengjia, Wang, Xiaocui, Zhu, Wengong, Yu, Qianhong, Gong   +4 more
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Effect of quorum sensing and quorum sensing inhibitors on the expression of serine protease gene in Hafnia alvei H4

Applied Microbiology and Biotechnology, 2020
The serp gene codes for a protease that is considered to be an important factor associated with quorum sensing (QS)-based food spoilage caused by microorganisms. In this study, we evaluated the effect of temperature (4-37 °C) and QS inhibitors on the production of N-acyl-L-homoserine lactones (AHLs) and relative expression of the luxR/I, as well as ...
Yaolei, Zhu, Xue, Sang, Xue, Li, Yanan, Zhang, Hongshun, Hao, Jingran, Bi, Gongliang, Zhang, Hongman, Hou   +7 more
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Quorum sensing inhibitors: a patent review (2014–2018)

Expert Opinion on Therapeutic Patents, 2018
Introduction: Quorum sensing (QS) is a cell density-dependent phenomenon in which specific pathways are activated after autoinducers (AIs) outside the microorganism reach a threshold concentration. QS creates a positive feedback loop that induces a cascade of gene expression and causes biofilm formation, virulence and sporulation.
Xin, Chen, Likun, Zhang, Mingxiang, Zhang, Huayu, Liu, Panrui, Lu, Kejiang, Lin   +5 more
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Quorum Sensing and Quorum Sensing Inhibitors of Natural Origin

2023
Nourhan G. Naga, Mona I. Shaaban
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