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Quorum sensing inhibitors as antipathogens: biotechnological applications
Biotechnology Advances, 2019The mechanisms through which microbes communicate using signal molecules has inspired a great deal of research. Microbes use this exchange of information, known as quorum sensing (QS), to initiate and perpetuate infectious diseases in eukaryotic organisms, evading the eukaryotic defense system by multiplying and expressing their pathogenicity through ...
Vipin Chandra Kalia +2 more
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A clash of quorum sensing vs quorum sensing inhibitors: an overview and risk of resistance
Archives of Microbiology, 2023Indiscriminate use of antibiotics to treat microbial pathogens has caused emergence of multiple drug resistant strains. Most infectious diseases are caused by microbes that are capable of intercommunication using signaling molecules, which is known as quorum sensing (QS). Such pathogens express their pathogenicity through various QS-regulated virulence
Rohit Patel +6 more
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Quorum sensing of pathogenic bacteria and quorum-sensing inhibitors
Chinese Science Bulletin, 2012The emergence of antibiotic-resistant and especially multidrug-resistant pathogenic bacteria intensifies the need to screen new drug targets and develop new antibacterial drugs. Bacteria coordinate their virulent behaviors in a cell density-dependent manner known as quorum sensing (QS).
ZongHui YUAN +4 more
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Inhibitors and antagonists of bacterial quorum sensing
Medicinal Research Reviews, 2008AbstractBacteria can regulate community‐wide behaviors including biofilm formation, virulence, conjugation, sporulation, and swarming motility through a process called quorum sensing. Inhibitors and antagonists of bacterial quorum sensing are important research tools and potential therapeutic agents.
Nanting, Ni +3 more
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Targeting Quorum Sensing in Pseudomonas Aeruginosa Biofilms: Current and Emerging Inhibitors
Future Microbiology, 2013 Bacterial resistance to conventional antibiotics combined with an increasing acknowledgement of the role of biofilms in chronic infections has led to a growing interest in new antimicrobial strategies that target the biofilm mode of growth.
Tim Holm Jakobsen +2 more
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Quorum sensing inhibitors: a patent overview
Expert Opinion on Therapeutic Patents, 2009Quorum sensing (QS) is a microbial cell-cell signaling system that correlates gene expression with cell population density. It plays important roles in intra-species communications and is also involved in inter-species and microbe-host interactions. Because QS controls a wide spectrum of phenotypes including virulence and biofilm formation, inhibition ...
Jiachuan, Pan, Dacheng, Ren
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Dihydropyrrolones as bacterial quorum sensing inhibitors
Bioorganic & Medicinal Chemistry Letters, 2019Bacteria regulate their pathogenicity and biofilm formation through quorum sensing (QS), which is an intercellular communication system mediated by the binding of signaling molecules to QS receptors such as LasR. In this study, a range of dihydropyrrolone (DHP) analogues were synthesized via the lactone-lactam conversion of lactone intermediates.
Basmah Almohaywi +8 more
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Dietary phytochemicals as quorum sensing inhibitors
Fitoterapia, 2007Quorum sensing (QS) is a cell density dependent expression of species in bacteria mediated by hormone like compounds called autoinducers (AI). Several processes responsible for successful establishment of bacterial infection are mediated by QS. Inhibition of QS is therefore being considered as a new target for antimicrobial chemotherapy.
D A, Vattem +3 more
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Nanomaterials as Quorum Sensing Inhibitors
2020Nano scale materials have unique physicochemical and optical properties due to their small particle size. They are finding increased application in the field of therapeutics and diagnostics. The antimicrobial properties of nanomaterials have been well investigated.
Jamuna A. Bai, V. Ravishankar Rai
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Quorum Sensing Inhibitors as Anti-Biofilm Agents
Current Pharmaceutical Design, 2014Biofilms are microbial sessile communities characterized by cells that are attached to a substratum or interface or to each other, are embedded in a self-produced matrix of extracellular polymeric substances and exhibit an altered phenotype compared to planktonic cells.
Gilles, Brackman, Tom, Coenye
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