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Discovery and evaluation of 3-(2-isocyanobenzyl)-1<i>H</i>-indole derivatives as potential quorum sensing inhibitors for the control of <i>Pseudomonas aeruginosa</i> infections <i>in vitro</i>. [PDF]

RSC Med Chem
Wang J, Yang JY, Durairaj P, Wen WH, Sabapathi N, Yang L, Wang B, Jia AQ.   +7 more
europepmc   +1 more source

Microbial Signals in Cancer: Dissecting Host–Microbiota–Tumor Interactions and Potential Therapeutic Strategy

MedComm, Volume 7, Issue 9, September 2026.
Microbial signals from gut and tumor‐resident bacteria, fungi, viruses, and bacteriophages reshape immune and metabolic networks within the tumor microenvironment, thereby influencing cancer progression, treatment response. Therapeutic modulations, including dietary interventions, probiotics, antibiotics, fecal microbiota transplantation, engineered ...
Juan Lu, Mengjuan Xuan, Liang Yu, Zhongyang Xie, Qingfei Chu, Shihui Wei, Tuokai Wang, Chen Xue, Lanjuan Li   +8 more
wiley   +1 more source

RNA programming towards predictable control of living bacterial therapeutics

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Na Li, Shengkun Tong, Lijie Yin, Yaojie Gao, Yaojun Tong   +4 more
wiley   +1 more source

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Quorum sensing inhibitors: An overview

Biotechnology Advances, 2013
Excessive and indiscriminate use of antibiotics to treat bacterial infections has lead to the emergence of multiple drug resistant strains. Most infectious diseases are caused by bacteria which proliferate within quorum sensing (QS) mediated biofilms.
Vipin Kalia
exaly   +3 more sources

A clash of quorum sensing vs quorum sensing inhibitors: an overview and risk of resistance

Archives of Microbiology, 2023
Indiscriminate use of antibiotics to treat microbial pathogens has caused emergence of multiple drug resistant strains. Most infectious diseases are caused by microbes that are capable of intercommunication using signaling molecules, which is known as quorum sensing (QS). Such pathogens express their pathogenicity through various QS-regulated virulence
Rohit Patel, Mansi Soni, Bilv Soyantar, Suruchi Shivangi, Swati Sutariya, Meenu Saraf, Dweipayan Goswami   +6 more
openaire   +2 more sources

Quorum sensing of pathogenic bacteria and quorum-sensing inhibitors

Chinese Science Bulletin, 2012
The emergence of antibiotic-resistant and especially multidrug-resistant pathogenic bacteria intensifies the need to screen new drug targets and develop new antibacterial drugs. Bacteria coordinate their virulent behaviors in a cell density-dependent manner known as quorum sensing (QS).
ZongHui YUAN, ZhenLi LIU, MengHong DAI, HaiHong HAO, GuYue CHENG   +4 more
openaire   +1 more source

Quorum sensing inhibitors as antipathogens: biotechnological applications

Biotechnology Advances, 2019
The mechanisms through which microbes communicate using signal molecules has inspired a great deal of research. Microbes use this exchange of information, known as quorum sensing (QS), to initiate and perpetuate infectious diseases in eukaryotic organisms, evading the eukaryotic defense system by multiplying and expressing their pathogenicity through ...
Yun Chan Kang, Jung-Kul Lee, Vipin Kalia   +2 more
exaly   +3 more sources

Dihydropyrrolones as bacterial quorum sensing inhibitors

Bioorganic & Medicinal Chemistry Letters, 2019
Bacteria regulate their pathogenicity and biofilm formation through quorum sensing (QS), which is an intercellular communication system mediated by the binding of signaling molecules to QS receptors such as LasR. In this study, a range of dihydropyrrolone (DHP) analogues were synthesized via the lactone-lactam conversion of lactone intermediates.
Basmah Almohaywi, Tsz Tin Yu, George Iskander, Daniel S.H. Chan, Kitty K.K. Ho, Scott Rice, David StC. Black, Renate Griffith, Naresh Kumar   +8 more
openaire   +3 more sources

Dietary phytochemicals as quorum sensing inhibitors

Fitoterapia, 2007
Quorum sensing (QS) is a cell density dependent expression of species in bacteria mediated by hormone like compounds called autoinducers (AI). Several processes responsible for successful establishment of bacterial infection are mediated by QS. Inhibition of QS is therefore being considered as a new target for antimicrobial chemotherapy.
D A, Vattem, K, Mihalik, S H, Crixell, R J C, McLean   +3 more
openaire   +2 more sources

Quorum sensing inhibitors: a patent overview

Expert Opinion on Therapeutic Patents, 2009
Quorum sensing (QS) is a microbial cell-cell signaling system that correlates gene expression with cell population density. It plays important roles in intra-species communications and is also involved in inter-species and microbe-host interactions. Because QS controls a wide spectrum of phenotypes including virulence and biofilm formation, inhibition ...
Jiachuan, Pan, Dacheng, Ren
openaire   +2 more sources