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Computational approaches for identifying quorum sensing inhibitors
Molecular DiversityQuorum sensing (QS) is a critical cell-to-cell communication mechanism employed by microorganisms to coordinate their collective behaviors, including biofilm formation, virulence regulation, and development of antimicrobial resistance (AMR). Disruption of QS using quorum sensing inhibitors (QSIs) has emerged as a promising anti-virulence strategy for ...
Lin, Zhong +6 more
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Quorum Sensing and Quorum Sensing Inhibitors of Natural Origin
2023Nourhan G. Naga, Mona I. Shaaban
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Advances in quorum-sensing inhibitors as novel therapeutic targets
Microbial PathogenesisThe growing antimicrobial resistance (AMR) has again prompted consideration of therapeutic strategies that reduce bacterial virulence rather than directly impairing viability. Quorum sensing (QS) is a density-dependent signaling network that controls the production of virulence factors, biofilm formation, metabolic reorganization, and interspecies ...
Israr Ansari +6 more
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Inhibitors and Antagonists of Bacterial Quorum Sensing
Medicinal Research Reviews, 2009Binghe Wang, Minyong Li, Nanting Ni
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Quorum-Sensing Inhibitors and Biofilms
Anti-Infective Agents in Medicinal Chemistry, 2009openaire +1 more source