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Inhibitors and antagonists of bacterial quorum sensing
Medicinal Research Reviews, 2008AbstractBacteria can regulate community‐wide behaviors including biofilm formation, virulence, conjugation, sporulation, and swarming motility through a process called quorum sensing. Inhibitors and antagonists of bacterial quorum sensing are important research tools and potential therapeutic agents.
Nanting, Ni +3 more
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Inhibition of marine biofouling by bacterial quorum sensing inhibitors [PDF]
Biofouling, 2011 Seventy eight natural products from chemical libraries containing compounds from marine organisms (sponges, algae, fungi, tunicates and cyanobacteria) and terrestrial plants, were screened for the inhibition of bacterial quorum sensing (QS) using a reporter strain Chromobacterium violaceum CV017.
Sergey Dobretsov +2 more
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Nanomaterials as Quorum Sensing Inhibitors
2020Nano scale materials have unique physicochemical and optical properties due to their small particle size. They are finding increased application in the field of therapeutics and diagnostics. The antimicrobial properties of nanomaterials have been well investigated.
Jamuna A. Bai, V. Ravishankar Rai
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Quorum sensing inhibitors: a patent review
Expert Opinion on Therapeutic Patents, 2013Quorum sensing (QS) is a cell-to-cell communication that regulates gene expression and coordinates their behavior in accordance with the cell population density as a result of discerning molecules termed autoinducers (AIs). The processes that QS governed include biofilm formation, bacterial virulence, antibiotic production, competence, conjugation ...
Tianyu, Jiang, Minyong, Li
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Biofilm and Quorum Sensing inhibitors: the road so far
Expert Opinion on Therapeutic Patents, 2020Biofilm is a complex aggregation of microorganisms characterized by the presence of a dynamic, adhesive and protective extracellular matrix composed of polysaccharides, proteins and nucleic acids. It is estimated that the vast majority of human infections are related to the biofilm in which the microorganisms reside and communicate with each other ...
Carradori S. +5 more
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Quorum Sensing Inhibitors as Anti-Biofilm Agents
Current Pharmaceutical Design, 2014Biofilms are microbial sessile communities characterized by cells that are attached to a substratum or interface or to each other, are embedded in a self-produced matrix of extracellular polymeric substances and exhibit an altered phenotype compared to planktonic cells.
Gilles, Brackman, Tom, Coenye
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Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors [PDF]
EMBO Journal, 2003 Traditional treatment of infectious diseases is based on compounds that kill or inhibit growth of bacteria. A major concern with this approach is the frequent development of resistance to antibiotics. The discovery of communication systems (quorum sensing systems) regulating bacterial virulence has afforded a novel opportunity to control infectious ...
Michael Givskov +2 more
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Fungal Quorum Sensing Inhibitors
2014Adaptation to various ecosystems is important to all microbes for growth and survival. Pathogenic microbes, especially bacteria, have developed mechanisms of synchronised expression of virulence genes with increasing population density through quorum sensing, enabling their survival in various host organisms.
Rohit Sharma, Kamlesh Jangid
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Microbial Pathogenesis, 2017
Antimicrobial therapy against extensively drug-resistant (XDR) P. aeruginosa biofilms is less efficient compared to the treatment of equal bacterial counts of free-floating planktonic cells, which has become a serious threat in hospital environment. P.
Ellappan, Kalaiarasan +5 more
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Antimicrobial therapy against extensively drug-resistant (XDR) P. aeruginosa biofilms is less efficient compared to the treatment of equal bacterial counts of free-floating planktonic cells, which has become a serious threat in hospital environment. P.
Ellappan, Kalaiarasan +5 more
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ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Weng C, Chan +2 more
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AbstractFor Abstract see ChemInform Abstract in Full Text.
Weng C, Chan +2 more
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