Results 221 to 230 of about 52,992 (283)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Iterative Multidisciplinary Development and Evaluation of a Patient-Facing Social Determinants of Health Chatbot Using Synthetic Data Simulation: Mixed Methods Study. [PDF]

JMIR Form Res
Maw AM, Lupi A, Johnson-Koenke R, Coats H, Zhou L, Li B, Mitchell J, Kotz A, Plasek J, Goss F.   +9 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Correction: Neuroimaging markers of aberrant brain activity and treatment response in schizophrenia patients based on brain complexity. [PDF]

Transl Psychiatry
Liu L, Li Z, Kong D, Huang Y, Wu D, Zhao H, Gao X, Zhang X, Yang M.   +8 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Patients' Experiences of Care During Hospitalization for Acute Respiratory Failure During COVID-19: A Multi-Center Qualitative Study. [PDF]

J Patient Exp
Jung YEG, Golden SE, Maxcy C, Hope AA, Hauschildt K, Valley TS, Wolwowicz E, Sarma N, Hough CL, Vranas KC.   +9 more
europepmc   +1 more source

Islamophobia in Canadian Nursing: An Interpretive Phenomenological Study Looking at the Experiences of Female Muslim Nurses. [PDF]

Can J Nurs Res
Upal Z, Jackson J.
europepmc   +1 more source

25, 50, and 75 Years Ago. [PDF]

ANZ J Surg
Smith JA.
europepmc   +1 more source

Leadership Development Sessions in a Community Health Setting: A Feasibility Evaluation of Participant-Perceived Leadership Preparedness. [PDF]

Cureus
Chanda V, Buchireddy S, Sawant A, Yarrabolu S, Baggerman E, Bhalala U.   +5 more
europepmc   +1 more source

Plagiarism - How to Use and Read it. [PDF]

J Orthop Case Rep
Vatkar AJ, Kale S, Shyam A, Shinde S.
europepmc   +1 more source