Results 211 to 220 of about 52,992 (283)

Organisational opportunities for person-centred care in residential aged care: a focus group study with managers and staff. [PDF]

BMJ Open
Østby RH, Dahlin-Ivanoff S, Najar J, Lood Q.   +3 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Novel emerging reassortant H6 avian influenza viruses with internal genes from G57 genotype of H9N2 pose potential zoonotic risk. [PDF]

Emerg Microbes Infect
Wan Z, Jiang W, Cao X, Guo X, He X, Zhang J, Chu X, Ji X, Liu Y, Yin X, Zhao Z, Wang J, Gao W, Xie Q, Li T, Shao H, Qin A, Bi Y, Ye J.   +18 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

North American Genetic Counselors' Perceptions of Identifiability From Demographic Questions on Surveys. [PDF]

J Genet Couns
Ramdaney A, Czerwinski J, Ashfaq M.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Isotope-free mapping of protein-RNA interactions at single-nucleotide resolution by iCLIP3. [PDF]

STAR Protoc
Despic V, Klostermann M, Orekhova A, Mesitov M, Busch A, Zarnack K, König J, Müller-McNicoll M.   +7 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

XLH Matters 2024 GCC Edition: Insights and Recommendations to Improve Outcomes for People Living With XLH in the Gulf Region. [PDF]

Clin Med Insights Endocrinol Diabetes
Seefried L, Al Badi M, Frookh H, Al-Sagheir A, Fiad TM, Deeb A, Al Sumaily A, Attia N, Habeb A, Alzahrani A, Mughal MZ.   +10 more
europepmc   +1 more source