Results 131 to 140 of about 8,764,171 (325)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The therapeutic effect of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol on chemically induced atopic dermatitis

Scientific Reports
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease worldwide. However, it is still urgent to develop innovative treatments that can effectively manage refractory patients with unpredictable chronic disease courses. In this study,
Su-Hyun Shin, Yu-Jin Kim, Su-Jin Kim, Guen Tae Kim, Hyowon Lee, Eun Young Kim, Se Hee Lee, Ki-Young Sohn, Jae Wha Kim, Jae Sam Lee   +9 more
doaj   +1 more source

Halichoeres burekae: Rocha, L.A., Collette, B.B., Grubbs, D., Pezold, F., Simons, J., Caruso, J., Carlson, J., McEachran, J.D., Brenner, J., Tornabene, L., Chakrabarty, P., Robertson, R., Claro, R., Carpenter, K.E., Vega-Cendejas, M., Camarena-Luhrs, T., Espinosa-Perez, H., Jelks, H., Williams, J. & Craig, M.T.

, 2014
IUCN
openalex   +1 more source

R&D as a prisoner’s dilemma and R&D - avoiding cartels

, 2011
Duopoly firms engaged in a standard two-stage game of R&D and Cournot competition are caught in a prisoner’s dilemma for their R&D decisions whenever spillover effects are low. This effect works to the advantage of consumers and society. This result provides an interesting perspective on the well-known wedge between private and social incentives for R ...
Rabah, Amir, Garcia, Filomena, Ermes, Christine H., Pais, Joana   +3 more
openaire   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Do R&D Subsidies Stimulate or Displace Private R&D? Evidence from Israel [PDF]

In evaluating the effect of an R&D subsidy we need to know what the subsidized firm would have spent on R&D had it not received the subsidy. Using data on Israeli manufacturing firms in the 1990s we find evidence suggesting that the R&D subsidies granted
Saul Lach
core  

Hibbertia tontoutensis: Veillon, J., Amice, R., Butin, J., Cazé, H., Garnier, D., Lannuzel, G., Leborgne, T. & McCoy, S.

, 2015
IUCN
openalex   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Comprehensive Comparison of Similarity Evaluation and Discovery of Weak Spectral Variations of Near-Infrared Spectroscopy for Tobacco Formulation Replacement

International Journal of Analytical Chemistry
Near-infrared (NIR) spectroscopy data encounter challenges in data processing such as peak overlapping, information redundancy, and background or noise, which complicate the evaluation of weak differences among similar samples.
Yipeng Zhang, Hui Jiang, Jun Ling, Liliang Wen, Keliang Yan, Aiming Chen, Zhongda Zeng, Miaomiao Wang, Qianxu Yang   +8 more
doaj   +1 more source

Oxychilus agostinhoi: Cameron, R., de Frias Martins, A.M. & Teixeira, D.

, 2016
IUCN
openalex   +1 more source