Results 171 to 180 of about 115,028 (266)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Graded Carbohydrate Ingestion up to 120 g·h^-1 Attenuates the Reduction in Critical Power Following 3 h of Moderate-Intensity Exercise in a Dose-Dependent Manner. [PDF]

Scand J Med Sci Sports
Norte BR, Slinn MM, Johnson KO, Mahon E, Shepherd SO, Strauss JA, Louis JB.   +6 more
europepmc   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Strengthening health systems in low and middle-income countries: performance determinants and pathways to universal health coverage. [PDF]

Front Health Serv
Sethy M, Mahapatro SR, Mundu GB, Sahoo DM.   +3 more
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

The Mediating Role of Adiposity in the Association Between Respiratory Muscle Strength and Exercise Energy Expenditure in Adult Women: A Cross-Sectional Study. [PDF]

J Clin Med
Aldhahi MI, Alhumaid D, Binshaye D, Almohsen F, Alotaibi R, Bahathiq L.   +5 more
europepmc   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Prevalence and risk factors of cognitive impairment among stroke survivors in India: an analysis of cross-sectional data from the Longitudinal Ageing Study in India. [PDF]

BMJ Open
Sooriyaarachchi P, Waller M, Nambiar V, Mohan D.   +3 more
europepmc   +1 more source

The Effects of R&D Tax Incentive Reform on R&D Expenditures: The Case of 2009 Reform in Japan

The Effects of R&D Tax Incentive Reform on R&D Expenditures: The Case of 2009 Reform in Japan
Tax incentives have been implemented in several countries, including Japan, to promote research and development (R&D). Several previous studies evaluate the effects of R&D tax incentives on R&D expenditures, but few address the changes in its conditions.
openaire  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source