Results 211 to 220 of about 115,028 (266)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

GFRAL is required to mediate changes in systemic metabolism in response to mitochondrial stress in brown adipose tissue. [PDF]

J Mol Med (Berl)
Sood A, Peterson J, Jena J, Challa V, Washburn C, Seeley RJ, Pereira RO.   +6 more
europepmc   +1 more source

Landscape of national antibiotic utilisation in Malaysia: an analysis of national pharmaceutical sales data from 2019 to 2023. [PDF]

J Pharm Policy Pract
Lim AH, Ab Rahman N, Nasarudin SNS, Mohamad Yahaya AH, Kamal M, Mohd Shah MS, Awang NH, Sim BLH, Chidambaram SK, Sivasampu S, Tok PSK.   +10 more
europepmc   +1 more source

Energetic Costs of Extreme Heat: High Temperatures Elevate Daytime Activity and Suppress Nighttime Foraging in Flying-Foxes. [PDF]

Ecol Evol
Walker MJ, Welbergen JA, Meade J, Boardman WSJ, Martin JM, Turbill C.   +5 more
europepmc   +1 more source

Correlation of parent-reported physical health-related quality-of-life with quantitatively measured physical function of former critically ill children. [PDF]

J Patient Rep Outcomes
Umman Serin N, Gunst J, Güiza F, Dulfer K, Verbruggen S, Joosten K, Van den Berghe G, Vanhorebeek I.   +7 more
europepmc   +1 more source

Effort produces after-effects costly for others but valued for self. [PDF]

Elife
Zheng Y, Tang R.
europepmc   +1 more source

Effects of a single dose of psilocybin on diet-induced weight loss in obese mice. [PDF]

Transl Psychiatry
Keenan RJ, Haque RT, Jin X, Mustafa T, Homman-Ludiye J, Elysee K, Wee ZS, Simonds SE, Foldi CJ, Cowley MA.   +9 more
europepmc   +1 more source

A Simple Game–theoretic Framework for studying R&D expenditures and R&D Cooperation

, 2001
openaire   +1 more source

R&D Expenditure, Patent, and the Uncertainty of Future Earnings

R&D Expenditure, Patent, and the Uncertainty of Future Earnings
openaire  

CAPITALIZING R&D EXPENDITURES [PDF]

Macroeconomic Dynamics, 2010
The next international version of the System of National Accounts will recommend that R&D (Research and Development) expenditures be capitalized instead of being immediately expensed as in the present System of National Accounts 1993. An R&D project creates a new technology, which in principle does not depreciate like a reproducible asset.
Diewert, Erwin, Huang, Ning
openaire   +1 more source