Results 81 to 90 of about 114,278 (267)
Financement régional des dépenses en recherche et développement
Brussels Studies, 2014 Following the loss of competitiveness of most European countries with respect to the other major economic powers since the 1970s, as part of its “Europe 2020” programme, the European Union has set the objective to allocate 3% of the GDP to research and ...
Hervé Devillé
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The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Determinants of corporate R&D expenditures: the role of taxes
, 2020 AT_PUBLICATION
Wasiluk, Dorota, Białek-Jaworska, Anna
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FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
SAGE OpenDigital transformation has accelerated corporate innovation and strengthened competitive advantage, yet its impact on one of the most critical innovation inputs—corporate R&D expenditure—remains underexplored.
Tingqian Pu
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Servitisation of manufacturing industry in Japan
Forum Scientiae Oeconomia, 2019 The recent decline in the profitability of Japanese manufac‑ turers has led to ‘service innovation’ or servitisation – the development of advanced service businesses utilising infor‑ mation technology.
Noriyuki Shikata +2 more
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Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
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Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Total Factor Productivity and the R & D Expenditures
Statistika, 2009 The total factor productivity (TFP) growth comes from improvements in the quality of labor and capital and from other sources of technological change, many of them in the form of externalities, spillovers, representing contributions of science and innovations in other enterprises, industries and countries.
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