Results 141 to 150 of about 5,017,645 (251)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

FUNDAMENTAL ECONOMIC STRUCTURE AND STRUCTURAL CHANGE IN REGIONAL ECONOMIES: A METHODOLOGICAL APPROACH [PDF]

Regional economic structure is defined as the composition and patterns of various components of the regional economy such as: produc-tion, employment, consumption, trade, and gross regional product.
Sudhir K. THAKUR
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Optimized reference region and the effect on test-retest reliability and sensitivity to differences between Parkinson's disease and control groups with [¹¹C]UCB-J. [PDF]

J Cereb Blood Flow Metab
Khattar N, Matuskey D, Gallezot JD, Naganawa M, Holmes SE, Ebrahimian Sadabad F, Mayeli M, Esterlis I, van Dyck CH, Mecca AP, D'Souza DC, Nabulsi NB, Finnema SJ, Huang Y, Carson RE, Toyonaga T.   +15 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Contrôle de l'émergence des adventices par le paillage en riziculture pluviale à Madagascar [PDF]

, 2012
Douzet, Jean-Marie, Irintsoa, Rasolofo, Naudin, Krishna, Rakotomalala, Andriamarosata, Scopel, Eric   +4 more
core  

THE ROLE OF DEVELOPMENT BANKING IN PROMOTING INDUSTRIALIZATION IN TURKEY [PDF]

Development banks are influential institutions in financing development. Since their establishment back in the 19th century, development banks have played a leading role in supporting development in many countries.
Derya GULTEKIN-KARAKAS, Hüseyin ÖZTÜRK, Mehtap HISARCIKLILAR   +2 more
core  

Optimization of Patient Skin Dose by C-Arm Angulation in Interventional Radiology for Spinal Vascular Lesions. [PDF]

J Neuroendovasc Ther
Tada T, Nishihori M, Sugimoto N, Mukoyama T, Sakai T, Uemura T, Koyama S, Tsutsumi Y, Izumi T, Goto S, Muraoka S, Takeuchi I, Saito R.   +12 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

National Courts and European environmental law: Belgian report on the case law 2001-2011 [PDF]

, 2012
Lavrysen, Luc
core   +1 more source