Results 151 to 160 of about 5,017,645 (251)

Ability to form Sox17-induced hematopoietic cell clusters varies among distinct hematopoietic sites during development. [PDF]

Inflamm Regen
Itabashi A, Yokoi Y, Saito K, Tsukahara R, Melig G, Azuma K, Iizuka N, Taga T, Nobuhisa I.   +8 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

EVALUATION WITHOUT BIAS: A METHODOLOGICAL PERSPECTIVE ON PERFORMANCE MEASURES FOR BUSINESS INCUBATORS [PDF]

Business growth and formation are fundamental drivers of job crea-tion and economic growth. Business incubators provide a nurturing environment, through an array of business support resources and services, where entrepre-neurs, start-ups, and small ...
Peter V. SCHAEFFER, Shaoming CHENG
core  

Cryo-EM structure of shutdown human nonmuscle myosin 2A. [PDF]

Sci Adv
Casas-Mao D, Carrington G, Peckham M.
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Empirical analysis of AS-level cooperation on the internet considering geopolitical characteristics. [PDF]

PLoS One
Nie J, Jin T, Wang Z, Fu C, Yu S, Xuan Q, Ruan Z.   +6 more
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Spatiotemporal interaction of tef head smudge disease (Curvularia spp.) and tef (Eragrostis tef) in the Western Amhara Region, Ethiopia, under the moderate (SSP245) and extreme (SSP285) climate change scenarios. [PDF]

PLoS One
Mekonnen MB, Abeje GD, Mekonnen MA.
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Epigenetic and Transcriptomic Impacts of Ethanol Vary by Brain Region and Extent of Exposure. [PDF]

eNeuro
Periandri EM, Dodson KM, Lopes M, de Luna Vitorino FN, Ola A, Gongora JM, Garcia BA, Glastad KM, Egervari G.   +8 more
europepmc   +1 more source