Results 91 to 100 of about 40,279 (236)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A importância das réplicas na valorização do património arqueológico da proto-história do noroeste peninsular

, 2012
As réplicas assumem um papel importante na valorização do património arquelógico, porque são, sem dúvida, um elemento gerador de receita de dinamização e valorização do património.
Moura, Jorge Olindo Pereira Martins de, Silva, Fátima Matos, orientador científico   +1 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Estimação de Whittle para réplicas de processos INAR

, 2004
Réplicas independentes de séries temporais são uma classe particular de medidas repetidas, em que a mesma resposta é medida ao longo do tempo em vários sujeitos (unidades experimentais).
Maria Eduarda Silva, Isabel Marques da Silva   +1 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Pressure induced increase of the exciton phonon interaction in ZnO/(ZnMg)O quantum wells

AIP Advances, 2016
It is a well-established experimental fact that exciton-phonon coupling is very efficient in ZnO. The intensities of the phonon-replicas in ZnO/(ZnMg)O quantum structures strongly depend on the internal electric field.
D. Jarosz, H. Teisseyre, A. Kamińska, A. Suchocki, A. Kozanecki   +4 more
doaj   +1 more source

Os corpos famintos e a Républica anestesiada: Réplicas e comentários adicionais a "Brasil 2020: tentativa de diagnóstico"

, 2021
Este artigo apresenta algumas réplicas e comentários adicionais a meu ensaio “Brasil, 2020: tentativa de ...
Lopes Gomes, David Francisco
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

User interest-aware content replica optimized placement algorithm

Tongxin xuebao, 2014
A user interest-aware content replica optimized placement algorithm (UIARP) is proposed.Firstly,the interest subjects of the user-collective are extracted from their content access logs by clustering algorithms,and according to the weighting of the ...
Xiao-long YANG, Xin-xin WANG, Min ZHANG, Ke-ping LONG, Qiong HUANG   +4 more
doaj   +2 more sources

Investigação Experimental do Balanceamento de Réplicas no Sistema de Arquivos do Apache Hadoop

, 2019
International audienceO mecanismo de replicação de dados é a base para o funcionamento do HDFS, o sistema de arquivos do Apache Hadoop. Seguindo uma política de posicionamento, as réplicas são dispostas entre os nós do cluster, porém não há garantias de ...
Fazul, Rhauani,, Pitthan Barcelos, Patricia   +1 more
core