Results 101 to 110 of about 45,350 (227)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
CRIAÇÃO DE RÉPLICAS 3D DE CERÂMICA ARQUEOLÓGICA
Este artigo destaca o uso de recursos tecnológicos para a criação de réplicas de cerâmicas arqueológicas a partir de um modelo tridimensional digital.
Santos, Adriano Márcio dos +4 more
core +1 more source
Esculturas talladas en piedra de réplicas precolombinas San Agustín Huila. [PDF]
, 2013 1 documento : 18 fotografías a color.Ilustraciones fotográficas de una pequeña colección de réplicas precolombinas talladas en piedra, cuyo diseño se inspira en el material arqueológico del Parque de San Agustín.
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Digital replicas and democracy: issues raised by the Hollywood actors’ strike
Humanities & Social Sciences CommunicationsRecent years have seen artificial intelligence (AI) technologies from large companies increasingly privatize people’s data, creating asymmetrical and undemocratic economic relations.
Asuka Yamazaki
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Energy-efficient and fast method on storage and querying in wireless sensor networks
Tongxin xuebao, 2008 This work, focuses on unstructured random data storage and query. Since the energy is one of the most pre- cious resources, an MESQ optimization problem is formed whose aim is to select the optimum number of replicas and queries that minimize the total ...
PENG Shao-liang +4 more
doaj +2 more sources
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
, 2023 Este documento define lo que es una réplica de un experimento clásico en psicología, al tiempo que identifica las consideraciones que el estudiante del pregrado en Psicología de la UCC campus Cali debe hacer antes de escoger el experimento a replicar ...
Ojeda Lopeda, Pablo César
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