Results 61 to 70 of about 298,783 (242)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
CFP - Les archives de la répression
, 2015 Journée d’étude : « Les archives de la répression ». Les doctorant.e.s du Laboratoire de Recherche Historique Rhône-Alpes (LARHRA, UMR 5190), organisent leur journée d’étude annuelle à Lyon le 20 octobre 2015, autour du thème des archives de la ...
modernum
core
Les luttes au sein d'un appareil de répression : l'armée bolivienne
, 1983 Lavaud Jean-Pierre. Les luttes au sein d'un appareil de répression : l'armée bolivienne. In: L'Homme et la société, N. 67-68, 1983. Répression emprise violence. pp.
Lavaud, Jean-Pierre
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Le réinvestissement de l’État dans la répression des crimes internationaux
, 2013 Quel est le rôle attribué aux États dans la répression des crimes internationaux et ce rôle a-t-il évolué depuis le procès de Nuremberg qui marque l’acte de naissance de la répression pénale internationale ?
Fourçans, Claire
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Répression : le dessus-dedans contre le dessous-dehors
, 1983 Joxe Alain. Répression : le dessus-dedans contre le dessous-dehors. In: L'Homme et la société, N. 67-68, 1983. Répression emprise violence. pp.
Joxe, Alain
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Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source