Results 21 to 30 of about 127,100 (203)

G-Material zur elementaren Gestaltung

Tr@jectoires, 2016
Cet article vise à souligner l’originalité de la revue G-Material zur elementaren Gestaltung, éditée par Hans Richter et Werner Gräff à Berlin de 1923 à 1926, par rapport à d’autres revues d’avant-garde, telles que De Stijl de Theo van Doesburg, Ma de ...
Livia Plehwe
doaj   +1 more source

La novela policiaca y la crisis

Cahiers d’Études Romanes, 2022
Cet article se penche sur le mécanisme narratif qui sous-tend le roman policier, soumis à un processus constant d’actualisation. En analysant la série Mario Conde de Leonardo Padura, l’article identifie les stratégies employées par l’auteur, dont l ...
Magdalena Tosik
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

L’idéologie marxiste de la révolution prolétarienne : la vision révolutionnaire des pays de l’Alliance des États du Sahel (AES) [PDF]

Pensées Genre, Penser Autrement
Cet article réexamine le marxisme révolutionnaire pour le comparer à la vision des pays de l’AES, considérés comme un laboratoire de transformation politique, économique et sociale en Afrique subsaharienne. L’auteur utilise une démarche diachronique pour
DJEKOLOBE DJETEUBBE
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

"Construindo a 'ordem anárquica'": algumas considerações em torno da doutrina social de Proudhon e Bakunin

Trans/Form/Ação, 1990
Este artigo pretende examinar alguns aspectos da doutrina social de Proudhon e de Bakunin, procurando relacioná-los com suas propostas de transformação social.
Patrícia Piozzi
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

« La femme Solitude de Guadeloupe »

Continents manuscrits, 2021
This paper seeks to unveil the long-winded creative process that led to André Schwarz-Bart’s 1972 novel La Mulâtresse Solitude. Relying on archival and unpublished materials, namely the autograph manuscript—partly written in calligraphy—and what remains ...
Catherine Rovera
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source