Results 101 to 110 of about 17,031,818 (292)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Factor analysis of posttraumatic stress disorder symptoms using data pooled from two venlafaxine extended-release clinical trials [PDF]

, 2013
BACKGROUND: Confirmatory factor analysis (CFA) of Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) (DSM-IV) three-factor posttraumatic stress disorder (PTSD) diagnostic criteria was conducted to determine fit for this patient ...
Stein, Dan J, Jonathan R. T. Davidson, Stein, D.J., Davidson, J.R.T., Rothbaum, Barbara O, Davidson, Jonathan RT, Pedersen, R., Baldwin, D.S., Szumski, Annette, Pedersen, Ronald, Dan J. Stein, Rothbaum, B.O., David S. Baldwin, Barbara O. Rothbaum, Annette Szumski, Baldwin, David S, Ronald Pedersen, Szumski, A.   +17 more
core   +1 more source

Geohazard linkages with surface geodynamics: a short-term temporal topographic analysis of mass movement and gradation patterns in the upper bhagirathi basin

Discover Applied Sciences
Surface dynamics are pivotal in shaping the Earth’s topography, which is convoluted with various geo-hazards such as mass movements and soil erosion processes.
Harish Khali, Rajat Subhra Chatterjee, Kishan Singh Rawat   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Productivity growth and R&D spillovers in Japanese manufacturing industry [PDF]

This paper estimates the contribution of R&D spillovers to productivity growth Japanese manufacturing industry by estimating two alternative measures of productivity growth and two different types of R&D spillovers. The results suggest that TFP growth is
Hyeog Ug Kwon
core  

Evidence supporting the use of recombinant activated factor VII in congenital bleeding disorders [PDF]

, 2010
Pär I Johansson, Sisse R OstrowskiCapital Region Blood Bank, Section for Transfusion Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, DenmarkBackground: Recombinant activated factor VII (rFVIIa, NovoSeven®) was introduced ...
Ostrowski, Sisse R., Pär I Johansson, Johansson, Pär I., Sisse R Ostrowski   +3 more
core   +1 more source

Exploratory Factor Analysis of SCL90-R Symptoms Relevant to Psychosis.

Iranian Journal of Psychiatry, 2016
Objective: Inconsistent results have been reported regarding the symptom dimensions relevant to psychosis in symptoms check list revised (SCL90-R), i.e., “psychoticism” and “paranoid ideation”.
Jafar Bakhshaie, Vandad Sharifi, Javad Amini   +2 more
doaj  

Complexity factor for static anisotropic self-gravitating source in f(R) gravity

European Physical Journal C: Particles and Fields, 2018
In a recent paper, Herrera (Phys Rev D 97:044010, 2018) have proposed a new definition of complexity for static self-gravitating fluid in general relativity.
G. Abbas, H. Nazar
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Factor structure of the Life Orientation Test-Revised (LOT-R)

Acta Colombiana de Psicología, 2017
Optimism and pessimism are conceptualized as generalized expectations about events happening in people's lives, and are regarded as stable dispositions. The construct of optimism can be understood as being one-dimensional and bipolar, in other words, it ...
Fernanda Ottati, Ana Paula Porto Noronha
doaj