Results 121 to 130 of about 27,605,430 (309)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Vision based feedback control of weatherstrip coextrusion with predictive dimension modeling

Scientific Reports
Achieving geometric accuracy in weatherstrip co-extrusion is inherently challenging due to the complex nonlinear interactions among process variables and the significant time delay caused by the long vulcanization line.
Donguk Lee, Thong Phi Nguyen, Hye-Jin Lee, Hyo-Kyung Kim, Sang-Min Lee, Gwi-Young Park, Jongseok Lee, Chanhee Won   +7 more
doaj   +1 more source

Design of Fast Response Back-Illuminated 3-D Composite Electrode Silicon Detector Utilizing the RIE-Lag Phenomenon

IEEE Journal of the Electron Devices Society
In this paper, a back-incidence 3D Composite Electrode Silicon Detector (3DCESD) is proposed and simulated. The electrode structure comprises 70% trench-like and 30% column-like features, achieved through a single etching step utilizing the
Wenzheng Cheng, Manwen Liu, Chenchen Zhang, Daimo Li, Zhihua Li   +4 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Impact of the therapeutic positioning report in the P&R process in Spain: analysis of orphan drugs approved by the European Commission and reimbursed in Spain from 2003 to 2019. [PDF]

Orphanet J Rare Dis, 2020
Badia X, Vico T, Shepherd J, Gil A, Poveda-Andrés JL, Hernández C.   +5 more
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The process engraver's monthly.

Numbering continuous.Mode of access: Internet.Feb.-Aug. 1895, 1899- , Nov. 1903, The Process photogram; Apr. 1896-Feb. 1898, The Process photogram and illustrator (continued as caption title to Nov.
Federation of Master Process Engravers.
core  

The Early R-Process Nucleosynthesis Scenarios

International Journal of Astronomy and Astrophysics
I compare seven actively studied r-process nucleosynthesis scenarios against observed properties of r-process elements in the early Universe, and conclude that the most likely scenario to contribute to the site of elements below the third r-process peak is the magnetorotational r-process scenario, and that of the third peak is the common envelope jets ...
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source