Results 141 to 150 of about 27,605,430 (309)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Evidence for supernova injection into the solar nebula and the decoupling of r-process nucleosynthesis. [PDF]
Proc Natl Acad Sci U S A, 2013 Brennecka GA, Borg LE, Wadhwa M.
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Concise Process Improvement Methods [PDF]
, 2011 This thesis reviews two methodologies for process improvement; Six Sigma and the Shainin System. A strengthened methodology is developed following the 12-step Six Sigma DMAIC cycle with an added Shainin loop in the Analyse phase to narrow down sources ...
COX, STEVEN
core
, 2023 This work aims to investigate on developing sustainable biogas/bio-syngas upgrading systems to green H2 and food grade CO2, through sorption-enhanced reforming (SER) and sorption-enhanced water gas shift (SEWGS) technologies.
Barbara Malsegna +4 more
core
Timing of the Penrose R-Process
, 2003 The Penrose reduction theory is applied to a particle/detector interaction where the time that it takes for a particle capture (and reduction of the original state) is constrained by the Heisenberg uncertainty between time and energy . The usual interpretation of this equation is found to conflict with the Hamiltonian dynamics of the interaction ...
openaire +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The NoiseFiltersR Package: Label Noise Preprocessing in R [PDF]
, 2017 In Data Mining, the value of extracted knowledge is directly related to the quality of the used data. This makes data preprocessing one of the most important steps in the knowledge discovery process.
Luengo, Julian +5 more
core
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source