From immune evasion to broad in silico binding: computational optimization of SARS-CoV-2 RBD-targeting nanobody [PDF]
Frontiers in ImmunologyIntroductionThe rapid evolution of SARS-CoV-2 Omicron variants highlights the urgent need for therapeutic strategies that can target viral evolution and leverage host immune recognition mechanisms.
Shuyuan Cao +4 more
doaj +2 more sources
Drug Metabolism and Pharmacokinetic Evaluation of a Novel RNase H2 Inhibitor for the Treatment of Triple-Negative Breast Cancer [PDF]
PharmaceuticsObjectives: A thorough understanding of pharmacokinetics and metabolism is critical during early drug development. This study investigates the absorption, distribution, metabolism, and excretion (ADME) profile of R14, a novel compound, using a ...
Yang Wang +7 more
doaj +2 more sources
Growth, sporulation and production of bioactive compounds by Bacillus subtilis R14 [PDF]
Brazilian Archives of Biology and Technology, 2010 The physiology of B. subtilis R14 was investigated in minimal medium under excess-oxygen and oxygen-limited conditions. Growth and efficient sporulation could be achieved in excess-oxygen culture on medium with readily metabolizable carbon and nitrogen ...
André Lacerda Ulysses de Carvalho +4 more
doaj +4 more sources
The study of thermodynamic properties of zeotropic mixtures of R600a/R23/R14 [PDF]
Advances in Mechanical Engineering, 2017 Thermodynamic properties of zeotropic mixtures of R600a/R23/R14 have been investigated and calculated based on the established mathematical model. The deviations of bubble pressure and vapor composition between the simulation results and the experimental
Yinlong Wu +4 more
doaj +2 more sources
A wild rice-derived peptide R14 ameliorates monosodium urate crystals-induced IL-1β secretion through inhibition of NF-κB signaling and NLRP3 inflammasome activation [PDF]
PeerJ, 2023 Gout is an inflammatory arthritis initiated by the deposition of monosodium urate crystals (MSU) around the joints and surrounding tissues. MSU crystals activate the nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3)
Supattra Charoenwutthikun +3 more
doaj +2 more sources
Diversification of agricultural activity in the territorial breakdown of Lubuskie Province
Folia Oeconomica Stetinensia, 2023 Each type of administrative unit, including cities, towns and villages, plays a different role in the regional economy. In the case of rural areas, their most important function is agricultural production.
Szczuciński Przemysław
doaj +1 more source
Microorganisms, 2020 Vibrio parahaemolyticus carrying binary toxin genes, pirAB, is one of the etiological agents causing acute hepatopancreatic necrosis disease (AHPND) in shrimp. This disease has emerged recently as a major threat to shrimp aquaculture worldwide.
Luis Fernando Aranguren Caro +4 more
doaj +1 more source
On the Assocıated Curves of a Frenet Curve in R_1^4
Cumhuriyet Science Journal, 2022 In the present work, we have dealt with the properties of associated curves of a Frenet curve in R14. In addition to this, we define principal direction curve, B_1 -direction curve, B_2- direction curve of a given Frenet curve by using integral curves ...
Mehmet Bektaş +2 more
doaj +1 more source
Baltic Journal of Real Estate Economics and Construction Management, 2022 In Costa Rica, a land tax valuation model provided by the Technical Standardization Body (ONT) of the Ministry of Finance is used. This model considers homogeneous areas that include properties with similar characteristics and review factors that have ...
Molina Javier Paniagua +3 more
doaj +1 more source
Experimental results and analysis of throttling refrigeration with ternary mixed refrigerant [PDF]
E3S Web of Conferences, 2021 In-depth analysis of the influence of mixed working fluids on the thermodynamic performance of a throttling refrigeration cycle through experimental research.
Ruonan Wang, Bin Liu, Haodong Liu
doaj +1 more source