Results 51 to 60 of about 1,105,597 (253)

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source

Venous Resection During Pancreatoduodenectomy for Pancreatic Cancer: A Systematic Review and Meta-Analysis

Life
Background: Venous resection during pancreatoduodenectomy is increasingly performed to achieve margin-negative resection in patients with pancreatic ductal adenocarcinoma involving the portomesenteric venous axis.
Dan Brebu, Flaviu Ionut Faur, Mircea Selaru, Cosmin Burta, Carmen Neamtu, Vlad Braicu, Ciprian Duta, Ioana Adelina Faur, Paul Pasca, Amadeus Dobrescu, Razvan Danau   +10 more
doaj   +1 more source

Return‐To‐Work and Working Status After Surgery for Gastric and Esophageal Cancer: A Prospective Observational Study

Annals of Gastroenterological Surgery, EarlyView.
In this multicenter prospective study of 158 working‐age patients undergoing curative‐intent surgery for gastric or esophageal cancer, 78.5% were working at 18 months. Postoperative appetite loss, financial difficulties, and ≥ 10% weight loss at 6 months were associated with non‐working status.
Kentaro Goto, Shigeo Hisamori, Kohei Ueno, Hiroyasu Abe, Ryosuke Okamura, Hisahiro Hosogi, Yoshito Yamashita, Dai Manaka, Hiroaki Hata, Tatsuto Nishigori, Sanae Nakajima, Michihiro Yamamoto, Koichi Kinoshita, Shintaro Okumura, Masazumi Sakaguchi, Shigeru Tsunoda, Yu Sakagami, Koya Hida, Kazutaka Obama   +18 more
wiley   +1 more source

Long-term oncological outcomes of endoscopic full-thickness resection after previous incomplete resection of low-risk T1 CRC (LOCAL-study): study protocol of a national prospective cohort study

BMC Gastroenterology, 2022
Background T1 colorectal cancer (CRC) without histological high-risk factors for lymph node metastasis (LNM) can potentially be cured by endoscopic resection, which is associated with significantly lower morbidity, mortality and costs compared to radical
L. W. Zwager, L. M. G. Moons, A. Farina Sarasqueta, M. M. Laclé, S. C. Albers, R. Hompes, K. C. M. J. Peeters, F. C. Bekkering, J. J. Boonstra, F. ter Borg, P. R. Bos, G. J. Bulte, E. A. R. Gielisse, W. L. Hazen, W. R. ten Hove, M. H. M. G. Houben, M. W. Mundt, W. B. Nagengast, L. E. Perk, R. Quispel, S. T. Rietdijk, F. J. Rando Munoz, R. J. J. de Ridder, M. P. Schwartz, R. M. Schreuder, T. C. J. Seerden, H. van der Sluis, B. W. van der Spek, J. W. A. Straathof, J. S. Terhaar Sive Droste, M. S. Vlug, W. van de Vrie, B. L. A. M. Weusten, T. D. de Wijkerslooth, H. J. Wolters, P. Fockens, E. Dekker, B. A. J. Bastiaansen, the Dutch eFTR Working Group   +38 more
doaj   +1 more source

Redefining the Role of Splenectomy in Scirrhous Gastric Cancer: Toward a Selective Multimodal Strategy

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Scirrhous gastric cancer, characterized by diffuse infiltration and a high propensity for peritoneal dissemination, remains one of the most aggressive subtypes of gastric cancer. Despite a relatively high incidence of splenic hilar lymph node (No. 10) metastasis, the oncologic benefit of splenectomy remains controversial, while its association
Tsutomu Hayashi, Takaki Yoshikawa
wiley   +1 more source

Additional file 3 of Prognostic impact of R1 resection margin in synchronous and simultaneous colorectal liver metastasis resection: a retrospective cohort study

, 2023
Additional file 3: Table S1. Demographic, clinicopathologic characteristics and recurrence pattern of parenchymal R1 versus vascular R1 resection patients with CRLM before and after propensity score matching (n = 64)
Na Reum Kim (16034705), Essam Dhafer Alhothaifi (16034708), Gi Hong Choi (14944620), Jin Sub Choi (16034711), Dai Hoon Han (4451119)   +4 more
core   +1 more source

One‐Year Changes in Frailty Components After Curative Minimally Invasive Surgery for Colorectal Cancer in Older Patients

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Frailty predicts outcomes after colorectal cancer surgery, but postoperative changes remain unclear. We previously reported improvement in FRAIL Scale‐based frail/pre‐frail status 1 year after curative minimally invasive surgery (MIS).
Hajime Ushigome, Takuya Suzuki, Shunsuke Hayakawa, Akira Kato, Yushi Yamakawa, Kenta Saito, Hiroyuki Sagawa, Ryo Ogawa, Hiroki Takahashi, Shuji Takiguchi   +9 more
wiley   +1 more source

Alveolar Echinococcosis—A Challenging Task for the Hepatobiliary Surgeon

Pathogens, 2021
(1) Background: Alveolar echinococcosis (AE) is an ultimately fatal disease, whose only curative treatment is surgery. Due to its late presentation extended liver resections are often necessary.
Jens Strohaeker, Mihaly Sulyok, Alfred Koenigsrainer, Silvio Nadalin   +3 more
doaj   +1 more source

Achievement of the Ideal Outcome After Pancreatectomy for Pancreatic Ductal Adenocarcinoma Is Associated With Earlier Initiation and Higher Completion Rates of Adjuvant Chemotherapy and Improved Long‐Term Survival

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background The Ideal Outcome is a composite quality indicator reflecting optimal postoperative course after pancreatic surgery. This study aimed to clarify the prognostic significance of achieving the Ideal Outcome and its influence on the initiation and completion of adjuvant chemotherapy.
Ryosuke Fukushima, Kenichiro Araki, Ryo Muranushi, Kouki Hoshino, Kei Hagiwara, Shunsuke Kawai, Mariko Tsukagoshi, Takamichi Igarashi, Norio Kubo, Ken Shirabe   +9 more
wiley   +1 more source

Comparison of tumour-based (Petersen Index) and inflammation-based (Glasgow Prognostic Score) scoring systems in patients undergoing curative resection for colon cancer [PDF]

, 2009
After resection, it is important to identify colon cancer patients, who are at a high risk of recurrence and who may benefit from adjuvant treatment. The Petersen Index (PI), a prognostic model based on pathological criteria is validated in Dukes' B and ...
Foulis, A.K., R F McKee, McMillan, D.C., A K Foulis, Maxwell, F., McKee, R.F., C S D Roxburgh, F Maxwell, Crozier, J.E.M., Roxburgh, C.S.D., Anderson, J.H., J H Anderson, D C McMillan, P G Horgan, J E M Crozier, Horgan, P.G., Brown, J., J Brown   +17 more
core   +1 more source