Generation of a Novel Col8a2<sup>P2A-CreERT2</sup> Mouse Line Enables Targeted Genetic Manipulation of Corneal Endothelial Cells and Modeling of Endothelial Decompensation. [PDF]
GenesisABSTRACT The corneal endothelium is a monolayer of specialized cells that maintains stromal deturgescence and transparency, functions essential for vision. Despite its clinical importance, the developmental origins and homeostatic programs of the endothelium remain poorly understood, in part due to the lack of a lineage‐specific genetic driver.
Yuan Y +9 more
europepmc +2 more sources
Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis
Hepatology, EarlyView., 2022 EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu +16 more
wiley +1 more source
Psychodynamic therapy: a poorly defined concept with questionable evidence [PDF]
, 2016 R34 MH086668 - NIMH NIH HHS; R01 AT007257 - NCCIH NIH HHS; R21 MH101567 - NIMH NIH HHS; R34 MH099311 - NIMH NIH HHS; R21 MH102646 - NIMH NIH HHS; K23 MH100259 - NIMH NIH HHS; R01 MH099021 - NIMH NIH ...
Hofmann, Stefan G.
core +1 more source
Interpersonal Emotion Regulation Questionnaire (IERQ): scale development and psychometric characteristics [PDF]
, 2016 Despite the popularity of emotion regulation in the contemporary literature, research has almost exclusively focused on only intrapersonal processes, whereas much less attention has been placed in interpersonal emotion regulation processes.
Carpenter, Joseph K. +2 more
core +1 more source
Scientific Reports, 2021 An effective vaccine would be a valuable tool for malaria control and elimination; however, the leading malaria vaccine in development, RTS,S/AS01, provided only partial protection in a Phase 3 trial. R21 is a next-generation RTS,S-like vaccine.
Katharine A. Collins +10 more
doaj +1 more source
Identification of a novel polyprenylated acylphloroglucinol‑derived SIRT1 inhibitor with cancer‑specific anti-proliferative and invasion-suppressing activities [PDF]
, 2014 SIRT1, a class III histone deacetylase, plays a critical role in regulating cancer cell growth, migration and invasion, which makes it a potential target for cancer therapeutics.
Chiao, Christine Ya-Chi +6 more
core +2 more sources
The Role of Listing Price Strategies on the Probability of Selling a House: Evidence from Vietnam
Real Estate Management and Valuation, 2020 The aim of this paper is to measure the dynamic effects of listing price strategies and housing features on the probability of selling a house over the marketing period by adopting a two-stage regression analysis.
Bich Hong Nguyen Thi +2 more
doaj +1 more source
A complex network perspective on clinical science [PDF]
, 2016 Contemporary classification systems for mental disorders assume that abnormal behaviors are expressions of latent disease entities. An alternative to the latent disease model is the complex network approach.
Curtiss, Joshua +2 more
core +2 more sources
EEG analytics for early detection of autism spectrum disorder: a data-driven approach [PDF]
, 2018 Autism spectrum disorder (ASD) is a complex and heterogeneous disorder, diagnosed on the basis of behavioral symptoms during the second year of life or later.
Bosl, William J. +2 more
core +2 more sources
3-Fluoro-N-(3-fluorobenzoyl)-N-(2-pyridyl)benzamide [PDF]
, 2009 The title compound, C19H12F2N2O2, a 2:1 product of the reaction of 3-fluorobenzoylchloride and 2-aminopyridine crystallizes with a disordered 3-fluorobenzene ring adopting two conformations [ratio of occupancies 0.959 (4):0.041 (4)].
Donnelly, Katie, Gallagher, John F.
core +1 more source