Results 61 to 70 of about 12,229 (180)
Exploration of Aromatic Hydrazides as Inhibitors of Human Carbonic Anhydrases
Archiv der Pharmazie, Volume 358, Issue 4, April 2025.Hydrazide‐based derivatives were evaluated as inhibitors of human carbonic anhydrase (hCA) isoforms I, II, IV, IX, and XII. Several derivatives, particularly those with ureido‐linkers, exhibited strong inhibitory activity with inhibition constants in the low micromolar range.
German Benito Menendez +5 more
wiley +1 more source
Advanced Science, Volume 12, Issue 11, March 20, 2025.This study reveals that obesity‐driven metabolic dysfunction enhances YAP O‐GlcNAcylation, facilitating its stabilization by preventing ubiquitylation and degradation via EIF3H, thereby driving TNBC progression and chemoresistance. Retatrutide disrupts this axis by suppressing O‐GlcNAcylation, restoring YAP ubiquitylation, and enhancing degradation ...
Xin Cui +9 more
wiley +1 more source
An Insect Effector Mimics Its Host Immune Regulator to Undermine Plant Immunity
Advanced Science, Volume 12, Issue 11, March 20, 2025.Under normal conditions, high OsGF14e expression recruits OsEDR1l and enhances OsEDR1l‐mediated MAPK cascade to restrict immunity and promote plant growth. Upon insect infestation, the OsGF14e signaling circuit is rewired toward active immune responses that confer resistance to BPH at the expense of growth.
Jianmei Fu +10 more
wiley +1 more source
Wall Street vs. Main Street: What are the Benefits and Costs of Wal-Mart to Local Communities? [PDF]
Community/Rural/Urban Development, L81, R52, R58,
Clark, Jill, Irwin, Elena G.
core +1 more source
Abacus, Volume 61, Issue 1, Page 218-238, March 2025.Crises such as COVID‐19 cause uncertainty that intensifies the pressure on public sector auditors, prompting them to question their established practices and routines. At the same time, stakeholders demand higher levels of assurance of public spending during crises.
Simona Caramia +2 more
wiley +1 more source
Real Estate Management and Valuation, 2019 The concept of market absorption and carrying capacity in economic terms are adequate to the real estate market, even though the legislator uses only the concept of the absorptive capacity of the area in the planning process.
Foryś Iwona, Kazak Jan
doaj +1 more source
THE STRUGGLE FOR BROADBAND IN RURAL AMERICA [PDF]
Broadband, Digital Divide, Economic Development, Infrastructure, Rural Development, Community/Rural/Urban Development, Research and Development/Tech Change/Emerging Technologies, L96, R11, R58,
Dickes, Lori A. +2 more
core +1 more source
Brain and Behavior, Volume 15, Issue 2, February 2025.To understand post‐intensive care syndrome (PICS) using Taiwan's National Health Insurance Research Database (NHIRD). ABSTRACT Purpose Intensive care unit (ICU) mortality has decreased, highlighting improved patient outcomes. However, other critical factors affect post‐ICU survival, including lasting physical, cognitive, and psychological challenges ...
Chen‐Shu Chang +2 more
wiley +1 more source
Distributional Impacts of Agritourism in the Arkansas Delta Byways region [PDF]
Replaced with revised version of paper 06/16/09.ARIMA, Agritourism Demand, Economic Impact Analysis, Rural Economic Development, Agribusiness, Community/Rural/Urban Development, R15, R58,
Das, Biswa R., Rainey, Daniel V.
core +1 more source
An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer [PDF]
, 2017 KRAS mutated tumours represent a large fraction of human cancers, but the vast majority remains refractory to current clinical therapies. Thus, a deeper understanding of the molecular mechanisms triggered by KRAS oncogene may yield alternative ...
Andersen, Jesper B. +22 more
core +3 more sources