Results 61 to 70 of about 1,668 (148)

Pulmonary‐Targeted Nanoparticles Interrupt the Malignant Mechanical and Biochemical Signaling Crosstalk for Idiopathic Pulmonary Fibrosis Therapy

Advanced Science, Volume 13, Issue 5, 27 January 2026.
Idiopathic pulmonary fibrosis (IPF) progression is driven by TGF‐β induced biochemical signals and mechanical signals from increased ECM stiffness. Pulmonary‐targeted VB‐RT NPs not only eliminate excessive ROS and penetrate the dense ECM collagen barrier via NO release, but also simultaneously interrupt the persistent malignant between mechanical and ...
Xue‐Na Li, Ya‐Ping Lin, Xi‐Xi Ma, Yue‐Fei Fang, Hui Wang, Chun‐Hui Cui, Chen Zhang, Jin‐You Piao, Jee‐Heon Jeong, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +11 more
wiley   +1 more source

Unveiling Antimalarial Drug Resistance: The Role of CRISPR‐Cas Technologies in Malaria Research

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2026, Issue 1, 2026.
Background Malaria, caused by Plasmodium parasites, remains a global health burden, with drug resistance threatening control efforts. CRISPR‐Cas technologies, particularly CRISPR‐Cas9, have transformed malaria research by enabling precise genetic manipulations to study antimalarial resistance mechanisms, develop novel therapeutics and enhance ...
Reuben Samson Dangana, Israel Ehizuelen Ebhohimen, Moses Okpeku, Jess Vergis   +3 more
wiley   +1 more source

A Cell‐Penetrating Scorpion Venom Peptide Disrupts the HSP90β‐PPARα Interaction to Ameliorate Metabolic Dysfunction‐Associated Steatotic Liver Disease

iMetaMed, Volume 1, Issue 2, December 2025.
In MASLD, increased HSP90β interacts with PPARα, thereby inhibiting PPARα activation via the inhibition of its nuclear translocation. BmK Tx‐2, a cell‐penetrating peptide from Buthus martensii Karsch scorpion venom, enters hepatocytes via macropinocytosis and escapes endosomes to bind HSP90β.
Erjin Xu, Wuguang Lu, Yonggen Chen, Ming Sang, Jiao Chen, Xueting Cai, Wenhao Xu, Yuxin Zhang, Zhiheng Wang, Feng Zhang, Peng Cao   +10 more
wiley   +1 more source

Mutational analysis of primary and advanced chordoma tissue using next‐generation sequencing

Cancer, Volume 131, Issue 16, 15 August 2025.
Abstract Background Chordomas are rare ectodermal bone malignancies derived from transformed notochordal remnants. Histologic variants include conventional (80%–90%), chondroid (5%–15%), and dedifferentiated (2%–8%). Because chordomas are relatively resistant to chemotherapy and radiotherapy, novel targeted agents are needed to expand treatment ...
Josh Chan, Joseph K. Kendal, Zhenfeng Duan, Al Ferreira, Alireza Samiei, Scott D. Nelson, Arun Singh, Elizabeth L. Lord, Brooke Crawford, Nicholas M. Bernthal, Francis J. Hornicek   +10 more
wiley   +1 more source

Identification of tiger and lion skulls: An illustrated guide for science and practice

Zoologica Scripta, Volume 54, Issue 3, Page 291-304, May 2025.
Abstract Tiger and lion bones are valuable subjects of trafficking. They can be easily interchanged. The aim of this study was to develop a methodology to quickly distinguish between tiger and lion skulls. From a number of features reported in the literature, a set of seven significant characters was identified that can be recognized even in ...
Dominika Formanova, Anna Kubatova
wiley   +1 more source

Exploration of Aromatic Hydrazides as Inhibitors of Human Carbonic Anhydrases

Archiv der Pharmazie, Volume 358, Issue 4, April 2025.
Hydrazide‐based derivatives were evaluated as inhibitors of human carbonic anhydrase (hCA) isoforms I, II, IV, IX, and XII. Several derivatives, particularly those with ureido‐linkers, exhibited strong inhibitory activity with inhibition constants in the low micromolar range.
German Benito Menendez, Simone Giovannuzzi, Alessandro Bonardi, Alessio Nocentini, Paola Gratteri, Claudiu T. Supuran   +5 more
wiley   +1 more source

“Absorption” or “Carrying Capacity” of Areas – Assessment Methods on the Example of Detached Housing Real Estate

Real Estate Management and Valuation, 2019
The concept of market absorption and carrying capacity in economic terms are adequate to the real estate market, even though the legislator uses only the concept of the absorptive capacity of the area in the planning process.
Foryś Iwona, Kazak Jan
doaj   +1 more source

Pharmacological Dissection Identifies Retatrutide Overcomes the Therapeutic Barrier of Obese TNBC Treatments through Suppressing the Interplay between Glycosylation and Ubiquitylation of YAP

Advanced Science, Volume 12, Issue 11, March 20, 2025.
This study reveals that obesity‐driven metabolic dysfunction enhances YAP O‐GlcNAcylation, facilitating its stabilization by preventing ubiquitylation and degradation via EIF3H, thereby driving TNBC progression and chemoresistance. Retatrutide disrupts this axis by suppressing O‐GlcNAcylation, restoring YAP ubiquitylation, and enhancing degradation ...
Xin Cui, Yueming Zhu, Lidan Zeng, Mengyuan Zhang, Amad Uddin, Theresa W. Gillespie, Lauren E. McCullough, Shaying Zhao, Mylin A. Torres, Yong Wan   +9 more
wiley   +1 more source

An Insect Effector Mimics Its Host Immune Regulator to Undermine Plant Immunity

Advanced Science, Volume 12, Issue 11, March 20, 2025.
Under normal conditions, high OsGF14e expression recruits OsEDR1l and enhances OsEDR1l‐mediated MAPK cascade to restrict immunity and promote plant growth. Upon insect infestation, the OsGF14e signaling circuit is rewired toward active immune responses that confer resistance to BPH at the expense of growth.
Jianmei Fu, Shuai Li, jing Li, Zhichang Zhao, Jing Li, Xinyang Tan, Shan Yu, Maofeng Jing, Keyan Zhu‐Salzman, Jichao Fang, Rui Ji   +10 more
wiley   +1 more source

Auditors’ Sensemaking During Crises: The Case of the COVID‐19 Pandemic in Italian Local Public Administrations

Abacus, Volume 61, Issue 1, Page 218-238, March 2025.
Crises such as COVID‐19 cause uncertainty that intensifies the pressure on public sector auditors, prompting them to question their established practices and routines. At the same time, stakeholders demand higher levels of assurance of public spending during crises.
Simona Caramia, Pasquale Ruggiero, Riccardo Mussari   +2 more
wiley   +1 more source