Results 121 to 130 of about 2,216,193 (279)

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

Skew cyclic codes over 𝔻4R and their applications to DNA codes construction

open access: yesAnalele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica
The fundamental aim of this research is to analyze the configuration of 𝔽4R submodules, skew cyclic codes over 𝔽4R and establish their connection with DNA codes, where 𝔽4 is a field of order 4 and R = 𝔽4 + u𝔽4 + v𝔽4 + w𝔽4 with u2 = u, v2 = v, w2 = w, uv =
Rehman Nadeem ur   +2 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

A Family of Optimal Linear Functional-Repair Regenerating Storage Codes

open access: yesEntropy
We construct a family of linear optimal functional-repair regenerating storage codes with parameters {m,(n,k),(r,α,β)}={(2r−α+1)α/2,(r+1,r),(r,α,1)} for any integers r,α with 1≤α≤r, over any field when α∈{1,r−1,r}, and over any finite field Fq with q≥r−1
Henk D. L. Hollmann
doaj   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

open access: yesFEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru   +6 more
wiley   +1 more source

F_p R – Linear Skew Constacyclic Codes

open access: yesAfyon Kocatepe University Journal of Sciences and Engineering
In this paper, we study a special class of linear codes, called skew constacyclic codes, over the ring F_p R, where R=F_p+vF_p, p is an odd prime number and v^2=v. These codes are defined as a subset of the ring F_p^m R^n. For an automorphism θ of R, we investigate the structural properties of skew polynomial ring R[x,θ].
openaire   +3 more sources

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

open access: yesFEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde   +3 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

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