Results 141 to 150 of about 5,246,646 (349)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Catching them early? Using a pre-arrival task to encourage first year students’ engagement with professionalism

, 2015
BackgroundMedical professionalism includes aspects of professional governance, professional patient care and personal and professional development (Owen, Hill & Stephens, 2009).
Lynch, Siobhan, Timm, Anja
core  

Centerscope [PDF]

, 1984
Centerscope, formerly Scope, was published by the Boston University Medical Center "to communicate the concern of the Medical Center for the development and maintenance of improved health care in contemporary society.
Annas, George J., Stengel, Elizabeth Bell   +1 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

The CYP3A5 genotypes of both liver transplant recipients and donors influence the time‐dependent recovery of tacrolimus clearance during the early stage following transplantation

Clinical and Translational Medicine, 2021
Li Huang, Abdullah A. Assiri, Peihao Wen, Kun Zhang, Junwei Fan, Tonghai Xing, Yuan Liu, Jinyan Zhang, Zhaowen Wang, Zhaojie Su, Jiajia Chen, Yi Xiao, Rui Wang, Risi Na, Liyun Yuan, Dehua Liu, Junjie Xia, Lin Zhong, Wanqing Liu, Wenzhi Guo, Brian R. Overholser, Zhihai Peng   +21 more
doaj   +1 more source

Regeneration process of severed rabbit common calcanean tendons influenced by external compression

Journal of Orthopaedic Surgery and Research
Background Limited research has focused on the correlation between an external compression and the regeneration of ruptured Achilles tendons. The aim of this study was to evaluate the influence of a constricted paratenon with external compression on the ...
Helin Wu, Xiaojing Dai, Lixia Huang, Xiaoyu Li, Shijun Wei, Feng Xu   +5 more
doaj   +1 more source

Burnout and satisfaction with work-life balance among US physicians relative to the general US population.

Archives of Internal Medicine, 2012
T. Shanafelt, S. Boone, Litjen L J Tan, Lotte N. Dyrbye, W. Sotile, D. Satele, C. West, J. Sloan, M. Oreskovich   +8 more
semanticscholar   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Lactylated Apolipoprotein C‐II Induces Immunotherapy Resistance by Promoting Extracellular Lipolysis

Advanced Science
Mortality rates due to lung cancer are high worldwide. Although PD‐1 and PD‐L1 immune checkpoint inhibitors boost the survival of patients with non‐small‐cell lung cancer (NSCLC), resistance often arises. The Warburg Effect, which causes lactate build‐up
Jian Chen, Deping Zhao, Yupeng Wang, Ming Liu, Yuan Zhang, Tingting Feng, Chao Xiao, Huan Song, Rui Miao, Li Xu, Hongwei Chen, Xiaoying Qiu, Yi Xu, Jingxuan Xu, Zelin Cui, Wei Wang, Yanchun Quan, Yifeng Zhu, Chen Huang, Song Guo Zheng, Jian‐yuan Zhao, Ting Zhu, Lianhui Sun, Guangjian Fan   +23 more
doaj   +1 more source