Results 51 to 60 of about 916,510 (294)
Inhibition of Ras oncogenic activity by Ras protooncogenes [PDF]
International Journal of Cancer, 2004 AbstractPoint mutations in ras genes have been found in a large number and wide variety of human tumors. These oncogenic Ras mutants are locked in an active GTP‐bound state that leads to a constitutive and deregulated activation of Ras function. The dogma that ras oncogenes are dominant, whereby the mutation of a single allele in a cell will predispose
Roberto, Diaz +8 more
openaire +2 more sources
ra-ve-n/CDC-nanoporous-carbon-ABOP: first_rel_30524
<p><strong>Full Changelog</strong>: https://github.com/ra-ve-n/CDC-nanoporous-carbon-ABOP/commits/first_rel_30524</p ...
ra-ve-n
core +1 more source
Haitian Landscape with Ra Ra Band
, 2022 Ra Ra band and people walking up a mountain toward a man on a white horse in the lower left; Ra Ra bands travel the country during Lent and, on Good Friday, they assemble in the coastal town of Leogane, where they perform and the best Ra Ra band is ...
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Characterization of Dermal Stem Cells of Diabetic Patients
Cells, 2019 Diabetic foot ulcers (DFUs) are lesions that involve loss of epithelium and dermis, sometimes involving deep structures, compartments, and bones. The aim of this work is to investigate the innate regenerative properties of dermal tissue around ulcers by ...
Letizia Ferroni +7 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
EFFECTS OF ANTIEPILEPTIC DRUGS ON LIPOPROTEIN (A) AND LIPID PROFILE
Eurasian Journal of Medicine, 2019 Purpose: Treatment with antiepileptic drugs is known to affect lipid concentrations in serum. However, little is known about the effects of anticonvulsant drugs (AEDs) on lipoprotein (a) [Lp(a)], although Lp(a) has been characterized as independent ...
Recep Aygül +4 more
doaj
raphiniert-com/ra-data-postgrest: v2.1.0
<ul> <li>see https://github.com/raphiniert-com/ra-data-postgrest/blob/master/CHANGELOG.md</li> </ul ...
Anthony Bernardo +14 more
core +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source