Results 61 to 70 of about 1,048,448 (240)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

In silico and in vitro evaluation of drug-like properties and anticancer potential of novel 5-fluorouracil derivatives

Scientific Reports
The development of more effective and safer anticancer agents remains a critical focus in cancer therapy. While biologics are gaining attention, small molecules continue to play a significant role due to their versatility and cost-effectiveness.
Kristine Harutyunyan, Lyudmila Nersesova, Violetta Ayvazyan, Emmi Avagyan, Merirouz Melkumyan, Maksim Sargsyan, Stepan Tatikyan, Zaven Karalyan, Hranush Avagyan, Arthur Harutyunyan, Gohar Tsakanova, Nelly Babayan   +11 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Endometrial cancer awareness as a public health blind spot: a cross-sectional survey study

BMC Public Health
Background Endometrial cancer is the most common gynecological cancer. With well-established risk factors and symptoms yet no early-detection screening test, patient-led symptom awareness is essential for early detection.
Bar Levy, Nitsan Schwarz, Yael Maizels, Orr Erlich, Zohar Magen, Zvi Vaknin   +5 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Teerk Roo Ra Residencies [PDF]

, 2011
A series of works based on the Peel Island Residencies on Teerk Roo Ra in Moreton Bay during 2010/2011.\ud \ud This work was part of a larger research project, which was concerned with using animation to convey a sense of place. The primary investigation
Denaro, Chris
core  

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Pêşgira Dariştinê ya “ra-”yê û Fonksîyonên Wê yên Morfosemantîk di Berhemên Klasîk ên Kurmancîya Jorîn da

Artuklu Kurdology
Mijara vê xebatê pêşgira dariştinê ya “ra-”yê û fonksîyonên wê yên morfosemantîk in. Dariştin yek ji rêbaza peyvsazîyê ye. Di vê rêbazê da gireyeke dariştinê li morfemeke xweser zêde dibe û maneyeke nû lê bar dike.
Ahmet Seyari
doaj  

Adapting Real-Time Lung Function Measurements for SARS-CoV-2 Infection Studies in Syrian Hamsters

Viruses
Pulmonary function examinations are critical to assess respiratory disease severity in patients. In preclinical rodent models of viral respiratory infections, however, disease is frequently evaluated based on virological, pathological and/or surrogate ...
Rineke de Jong, Wout Nuiten, Albertjan ter Heide, Wilfred Hamstra, Sandra Vreman, Nadia Oreshkova, Katrin E. Wiese, Nora M. Gerhards   +7 more
doaj   +1 more source

Effects of Raloxifene (RAL) on proliferation in healthy (H) and rheumatoid arthritis (RA) synoviocytes

, 2011
Copyright information:Taken from "Raloxifene reduces urokinase-type plasminogen activator-dependent proliferation of synoviocytes from patients with rheumatoid arthritis"Arthritis Research & Therapy 2005;7(6):R1244-R1253.Published online 8 Sep 2005PMCID ...
R Livi (60646), A Rossi (60647), S Guiducci (60642), A Gabrielli (60648), N Iori (60650), G Fibbi (60651), M Cinelli (60644), F Perfetto (60645), M Del Rosso (60652), M Matucci Cerinic (60653), R Giacomelli (60649), A Del Rosso (60643)   +11 more
core   +1 more source