Results 71 to 80 of about 1,048,448 (240)

Self-reported adult footwear and the risks of lower limb osteoarthritis : the GOAL case control study [PDF]

, 2014
Background: Biomechanical factors may play a role in osteoarthritis (OA) development and progression. Previous biomechanical studies have indicated that types of footwear may modulate forces across the knee joint, and high heeled womens’ shoes in ...
Muthuri, Stella, Weiya Zhang, Zhang, W, Muthuri, S, Rose A Maciewicz, Maciewicz, Rose A., Muir, Kenneth, Doherty, M, Stella Muthuri, McWilliams, Daniel F., McWilliams, D F, Daniel F McWilliams, Muir, Kenneth R., Maciewicz, R A, Kenneth R Muir, Michael Doherty, Zhang, Weiya, Muir, K R; id_orcid, Doherty, Michael   +18 more
core   +2 more sources

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Optimizing drug design by merging generative AI with a physics-based active learning framework

Communications Chemistry
Machine learning is transforming drug discovery, with generative models (GMs) gaining attention for their ability to design molecules with specific properties. However, GMs often struggle with target engagement, synthetic accessibility, or generalization.
Isaac Filella-Merce, Alexis Molina, Lucía Díaz, Marek Orzechowski, Yamina A. Berchiche, Yang Ming Zhu, Júlia Vilalta-Mor, Laura Malo, Ajay S. Yekkirala, Soumya Ray, Victor Guallar   +10 more
doaj   +1 more source

Characterization of Edwardsiella Strains Isolated from Fish in The Netherlands (1995–2020) Shows a Relationship Between Edwardsiella Species and Source

Pathogens
To date, four species of the genus Edwardsiella—E. tarda, E. ictaluri, E. piscicida, and E. anguilarum—have been identified as the cause of disease and mortality in various fish species.
Janneke Allaart, Andries Kampfraath, Frank Harders, Michal Voorbergen-Laarman, Betty van Gelderen, Belén Fouz, Marc Engelsma   +6 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Porcine Airway Organoid-Derived Well-Differentiated Epithelial Cultures as a Tool for the Characterization of Swine Influenza a Virus Strains

Viruses
Swine influenza A viruses (IAVsw) are important causes of disease in pigs but also constitute a public health risk. IAVsw strains show remarkable differences in pathogenicity. We aimed to generate airway organoids from the porcine lower respiratory tract
Nora M. Gerhards, Manouk Vrieling, Romy Dresken, Sophie Nguyen-van Oort, Luca Bordes, Jerry M. Wells, Rik L. de Swart   +6 more
doaj   +1 more source

Aerolíneas Galápagos... ¡ra! ¡ra! ¡ra! [PDF]

, 2002
Aerolíneas Galápagos... ¡RA! ¡RA! ¡RA!Las Aerolíneas Galápagos (AEROGAL) con el placer de todos los ecuatorianos que usamos el avión, anuncia con un equipo Boeing727-200 Advance, con matricula HC-CDJ, equipado con turbinas PyWJT8D-17; y con capacidad ...
Tobar Vega, Hugo
core  

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Teucrium Polium ameliorates amyloid β-induced brain network disorders in rats: electrophysiological and behavioral studies

BMC Complementary Medicine and Therapies
Synaptic failure in specific cholinergic networks in rat brains has been implicated in amyloid β-induced neurodegeneration. Teucrium polium is a promising candidate for drug development against Alzheimer’s disease (AD) and similar disorders. However, the
Karen Simonyan, Lilit Darbinyan, Lilia Hambardzumyan, Larisa Manukyan, Vergine Chavushyan   +4 more
doaj   +1 more source

Co-Cultivation of Komagataeibacter xylinus MS2530 with Various Yeast Strains: Production and characterization of bacterial cellulose Films

Carbohydrate Polymer Technologies and Applications
High production costs and low yield of bacterial cellulose (BC) remain major impediments to the large-scale industrial production of BC. Therefore, the cost reduction through utilization of inexpensive cultivation media, such as recycled industrial waste,
Marina Paronyan, Lusine Saghatelyan, Sona Avetisyan, Haykanush Koloyan, Marina Kinosyan, Valeri Bagiyan, Susanna Hovhannisyan, Olga Akopian, Anichka Hovsepyan   +8 more
doaj   +1 more source