Results 101 to 110 of about 73,139 (321)

Rab GTPases as Physiological Substrates of LRRK2 Kinase

Experimental Neurobiology, 2019
LRRK2 (Leucine-Rich Repeat Kinase 2) is a gene whose specific mutations cause Parkinson's disease (PD), the most common neurodegenerative movement disorder. LRRK2 harbors GTPase and kinase activities, two enzyme activities that play critical roles in the
W. Seol, Daleum Nam, I. Son
semanticscholar   +1 more source

Development of a Highly Sensitive Time‐Resolved Fluorescence Immunochromatographic Assay for Rapid Onsite Determination of Prometryn Residues in Food Samples

Food Safety and Health, EarlyView.
The recombinant full‐length antibody against prometryn (PRO‐rAb) was prepared by HEK293 (F) cell expression system and utilized as the foundation for time‐resolved fluorescence immunochromatographic assay (TRFICA). The established method showed good performance for the detection of prometryn residues in five food samples. ABSTRACT Prometryn, a triazine
Jing Zhao, Song Gao, Peipei Li, A. M. Abd El‐Aty, Lingyuan Xu, Fen Jin, Jing Wang, Jia Li, Weiping Lin, Lufei Zheng, Bining Jiao   +10 more
wiley   +1 more source

Thematic review series: Lipid Posttranslational Modifications. Geranylgeranylation of Rab GTPases

Journal of Lipid Research, 2006
Rab GTPases require special machinery for protein prenylation, which include Rab escort protein (REP) and Rab geranylgeranyl transferase (RGGT). The current model of Rab geranylgeranylation proposes that REP binds Rab and presents it to RGGT.
Ka Fai Leung, Rudi Baron, Miguel C. Seabra   +2 more
doaj   +1 more source

Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration

Molecular Neurodegeneration, 2018
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial and sporadic Parkinson’s disease (PD). Elevated kinase activity is associated with LRRK2 toxicity, but the substrates that mediate neurodegeneration remain poorly ...
Ga Ram Jeong, Eun-Hae Jang, Jae Ryul Bae, Soyoung Jun, H. Kang, Chi-Hu Park, Joo-Ho Shin, Yukio Yamamoto, Keiko Tanaka-Yamamoto, V. Dawson, T. Dawson, E. Hur, B. D. Lee   +12 more
semanticscholar   +1 more source

Direct versus referred admission to the maternity hospital due to preeclampsia: Does it influence pregnancy outcomes?

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objectives This study describes maternal and perinatal outcomes of women with preeclampsia (PE) according to hospital admission characteristics: referral from lower complexity settings or directly admitted at the reference hospital. Methods This is a cross‐sectional study considering women with PE who were admitted for childbirth between ...
Juliana da‐Costa‐Santos, Guilherme F. Borges, Vitor L. V. Reis, Rodolfo R. Japecanga, Maykon A. Carvalho, Ana Julia G. Oliveira, Laura C. Vinchi, Arthur B. P. Righi, Jussara Mayrink, Fernanda G. Surita, José Paulo de Siqueira Guida, Renato T. Souza, José G. Cecatti, Maria Laura Costa   +13 more
wiley   +1 more source

The small GTPase RAB-35 defines a third pathway that is required for the recognition and degradation of apoptotic cells.

PLoS Genetics, 2018
In metazoans, apoptotic cells are swiftly engulfed by phagocytes and degraded inside phagosomes. Multiple small GTPases in the Rab family are known to function in phagosome maturation by regulating vesicle trafficking.
Ryan Haley, Ying Wang, Zheng Zhou
doaj   +1 more source

Multiple Requirements for Rab GTPases in the Development of Drosophila Tracheal Dorsal Branches and Terminal Cells [PDF]

, 2020
Benedikt T. Best, Maria Leptin
openalex   +1 more source

Rab GTPases in Immunity and Inflammation

Frontiers in Cellular and Infection Microbiology, 2017
Strict spatiotemporal control of trafficking events between organelles is critical for maintaining homeostasis and directing cellular responses. This regulation is particularly important in immune cells for mounting specialized immune defenses.
A. Prashar, L. Schnettger, Elliott M. Bernard, M. Gutierrez   +3 more
semanticscholar   +1 more source

Suppressing vertical aluminum growth via accelerated interfacial Cl− dynamics for high‐areal‐capacity, long‐life aluminum metal anodes

InfoMat, EarlyView.
Through systematic analysis, we identified that cell failure of aluminum metal anodes via electrode short circuits arises from inefficient Cl− removal, which promotes vertical Al growth through localized reaction product accumulation. To address this, we developed a 3D nanostructured graphitic carbon electrode (3D‐GCE) and a Cl‐doped polypropylene (Cl ...
Yeong Hoon Heo, Juhee Yoon, Minhyuck Park, Do Hyun Kim, Jong Chan Hyun, Sion Kim, Jimin Park, Jisoo Kim, Son Ha, Jiyun Yeon, Jeonghun Lee, Hyoung‐Joon Jin, Hyung‐Kyu Lim, Young Soo Yun   +13 more
wiley   +1 more source

RAB21 Activity Assay Using GST-fused APPL1

Bio-Protocol, 2016
The Rab family of small GTPases are essential regulators of membrane trafficking events. As with other small GTPase families, Rab GTPases cycle between an inactive GDP- bound state and an active GTP-bound state. Guanine nucleotide exchange factors (GEFs)
Steve Jean, Amy Kiger
doaj   +1 more source